1 00:00:13,722 --> 00:00:15,681 I read this piece in "The Times" 2 00:00:15,765 --> 00:00:17,683 about this little girl who needs a new windpipe. 3 00:00:17,767 --> 00:00:19,477 Name's Hannah Warren. 4 00:00:19,561 --> 00:00:21,103 Her family's working with this doctor in Europe. 5 00:00:21,187 --> 00:00:23,272 Dr. Paolo Macchiarini. 6 00:00:23,356 --> 00:00:25,816 The focus of my research is tracheal transplants 7 00:00:25,900 --> 00:00:27,693 with the help of stem cells 8 00:00:27,777 --> 00:00:31,030 by developing biosynthetic tracheas. 9 00:00:31,114 --> 00:00:32,531 So you're basically tricking the body 10 00:00:32,615 --> 00:00:34,325 into thinking the implant's already a part of you. 11 00:00:34,409 --> 00:00:36,661 Will you be interested in assisting? 12 00:00:36,745 --> 00:00:37,995 Yes. Yes. 13 00:00:38,079 --> 00:00:39,622 I was wondering if you would be interested 14 00:00:39,706 --> 00:00:42,208 in collaborating on rat trials to test our tracheas. 15 00:00:42,292 --> 00:00:44,252 - Absolutely. - Welcome to the team. 16 00:00:44,336 --> 00:00:46,254 So this is the first artificial-trachea transplant 17 00:00:46,338 --> 00:00:48,005 in the U.S., 18 00:00:48,089 --> 00:00:50,758 and I want Hannah's journey to be the focus of the piece. 19 00:00:50,842 --> 00:00:52,134 Surgery went well. 20 00:00:52,218 --> 00:00:54,845 I have watched you for a while now. 21 00:00:54,929 --> 00:00:56,722 What you did, it was a miracle. 22 00:00:56,806 --> 00:01:00,518 Paolo, I shouldn't. 23 00:01:00,602 --> 00:01:02,770 The science doesn't seem sound. 24 00:01:02,854 --> 00:01:04,563 It's not exactly your kind of science. 25 00:01:04,647 --> 00:01:08,401 I will admit I don't get it. 26 00:01:08,485 --> 00:01:09,694 Knife. 27 00:01:09,778 --> 00:01:12,405 After the operation, she's healthy and happy 28 00:01:12,489 --> 00:01:13,782 with her donor trachea. 29 00:02:46,708 --> 00:02:49,794 Hannah Warren will be the youngest patient 30 00:02:49,878 --> 00:02:53,047 ever to receive a biosynthetic tracheal transplant. 31 00:02:53,131 --> 00:02:54,799 Okay, stop right there. 32 00:02:54,883 --> 00:02:58,594 Let's swap this out to play over Dr. Macchiarini talking 33 00:02:58,678 --> 00:03:00,888 about the initial diagnosis. 34 00:03:00,972 --> 00:03:03,349 I think we still need a little more B-roll 35 00:03:03,433 --> 00:03:06,686 with the parents, but we are close to locking. 36 00:03:06,770 --> 00:03:08,187 Ow. 37 00:03:08,271 --> 00:03:09,563 - You okay? - Yeah, I'm okay. 38 00:03:15,153 --> 00:03:16,487 Hi. 39 00:03:16,571 --> 00:03:18,781 I was just talking about you. 40 00:03:18,865 --> 00:03:21,158 Uh, Benita. 41 00:03:21,242 --> 00:03:22,827 Daryl? 42 00:03:22,911 --> 00:03:24,203 I called to, um-- 43 00:03:24,287 --> 00:03:26,998 I called to tell you she, uh-- 44 00:03:27,082 --> 00:03:28,332 she's gone. 45 00:03:28,416 --> 00:03:30,793 What? 46 00:03:30,877 --> 00:03:33,212 Hannah's gone. 47 00:03:33,296 --> 00:03:37,383 What--what do you mean she's gone? 48 00:03:37,467 --> 00:03:39,844 It was-- There were complications. 49 00:03:39,928 --> 00:03:43,889 Her--her lungs, after all the time in the hospital, 50 00:03:43,973 --> 00:03:48,019 she just-- her body couldn't, um... 51 00:03:48,103 --> 00:03:50,229 Hannah's gone. 52 00:03:50,313 --> 00:03:53,524 We were with her, and she just kept getting worse. 53 00:03:53,608 --> 00:03:56,152 We thought maybe she was gonna-- 54 00:03:56,236 --> 00:03:58,404 that it would pass, but, uh-- 55 00:04:09,416 --> 00:04:12,043 Mom, your phone. 56 00:04:19,801 --> 00:04:23,013 - Is it work? - No, it's not work. 57 00:04:24,472 --> 00:04:26,599 What's up with the braids, kiddo? 58 00:04:26,683 --> 00:04:29,560 I haven't seen you repeat a hairstyle twice, 59 00:04:29,644 --> 00:04:33,397 let alone three times, in a week. 60 00:04:33,481 --> 00:04:35,817 Dad liked my hair this way. 61 00:04:41,448 --> 00:04:44,533 I miss him, too. 62 00:04:44,617 --> 00:04:47,912 But I think you look great. 63 00:04:47,996 --> 00:04:49,288 You ready for school? 64 00:05:05,430 --> 00:05:07,056 What are you doing here? 65 00:05:07,140 --> 00:05:08,849 I wanted to make sure that you're okay. 66 00:05:08,933 --> 00:05:11,143 You're not answering my phone calls, my texts. 67 00:05:11,227 --> 00:05:12,520 You shouldn't be here. 68 00:05:12,604 --> 00:05:14,773 I know you heard about Hannah. 69 00:05:17,692 --> 00:05:22,321 I just wanted to make sure that you're okay, Benita. 70 00:05:22,405 --> 00:05:24,907 I thought she was getting better. 71 00:05:24,991 --> 00:05:27,451 - There were complications. - "Complications. 72 00:05:27,535 --> 00:05:28,869 "Fragile native tissue. 73 00:05:28,953 --> 00:05:30,204 Weakening of the lungs." 74 00:05:30,288 --> 00:05:33,457 I-I read the reports, Paolo. I know the medicine. 75 00:05:33,541 --> 00:05:36,586 But you told me she was getting better. 76 00:05:36,670 --> 00:05:40,172 She was very sick. 77 00:05:40,256 --> 00:05:42,883 And she was going to die. 78 00:05:42,967 --> 00:05:44,135 I tried. 79 00:05:46,680 --> 00:05:49,307 You think that I'm not upset? 80 00:05:49,391 --> 00:05:51,517 But I won't give up. 81 00:05:51,601 --> 00:05:54,061 I don't have the right to give up. 82 00:05:54,145 --> 00:05:58,524 No, Paolo, don't. I-I can't do this. 83 00:05:58,608 --> 00:06:02,194 Let's just call it what it is, okay? 84 00:06:02,278 --> 00:06:04,530 What is it? 85 00:06:04,614 --> 00:06:06,616 A mistake. 86 00:06:08,868 --> 00:06:10,661 Colleagues, board members, 87 00:06:10,745 --> 00:06:12,663 we are so glad to have you here 88 00:06:12,747 --> 00:06:14,248 for this momentous occasion. 89 00:06:14,332 --> 00:06:18,502 Tomorrow we will perform the first-ever human transplant 90 00:06:18,586 --> 00:06:20,796 using a bioartificial scaffold. 91 00:06:20,880 --> 00:06:23,507 Our patient is Andemariam Beyene, 92 00:06:23,591 --> 00:06:26,969 a 36-year-old Eritrean PhD student 93 00:06:27,053 --> 00:06:28,679 living in Iceland. 94 00:06:28,763 --> 00:06:31,474 Two years ago, he developed a malignant tumor 95 00:06:31,558 --> 00:06:33,100 in his windpipe. 96 00:06:33,184 --> 00:06:37,021 They have tried radiation and surgical intervention. 97 00:06:37,105 --> 00:06:38,356 All failed. 98 00:06:38,440 --> 00:06:41,525 So his doctors referred him to us. 99 00:06:41,609 --> 00:06:43,194 As you all know, we only have approval 100 00:06:43,278 --> 00:06:46,989 to perform this procedure as compassionate use, 101 00:06:47,073 --> 00:06:48,366 a last resort. 102 00:06:48,450 --> 00:06:50,701 We have designed a biosynthetic trachea 103 00:06:50,785 --> 00:06:53,496 tailor-made to Mr. Beyene's anatomy, 104 00:06:53,580 --> 00:06:55,748 down to the last micrometer. 105 00:06:55,832 --> 00:06:58,000 And this truly is the breakthrough 106 00:06:58,084 --> 00:07:00,753 that will launch us as a global destination 107 00:07:00,837 --> 00:07:02,505 for this kind of medicine. 108 00:07:02,589 --> 00:07:03,923 Ladies and gentlemen, 109 00:07:04,007 --> 00:07:08,094 I present to you the future of regenerative medicine. 110 00:07:11,723 --> 00:07:13,891 Within weeks, it will grow tissue, 111 00:07:13,975 --> 00:07:17,228 transforming into an actual, living trachea. 112 00:07:24,319 --> 00:07:27,488 Dr. Macchiarini, I am sorry. 113 00:07:27,572 --> 00:07:30,533 I no longer wish to have the surgery. 114 00:07:30,617 --> 00:07:33,828 We feel it is too risky. 115 00:07:33,912 --> 00:07:38,249 It is completely natural to have concerns, Mr. Beyene. 116 00:07:38,333 --> 00:07:39,917 The trachea, it's plastic. 117 00:07:40,001 --> 00:07:42,712 How can you be sure it will work inside my body? 118 00:07:42,796 --> 00:07:45,047 There you misunderstand. 119 00:07:45,131 --> 00:07:46,549 It is not plastic. 120 00:07:46,633 --> 00:07:48,843 The trachea is medical-grade 121 00:07:48,927 --> 00:07:52,638 polymeric nano-composite material. 122 00:07:52,722 --> 00:07:55,016 - If I may. - Yeah, of course. 123 00:07:55,100 --> 00:07:58,227 Mr. Beyene, you're studying lava tubes in Iceland. 124 00:07:58,311 --> 00:07:59,854 - Is that right? - Yes. 125 00:07:59,938 --> 00:08:01,647 I believe the recellularization process 126 00:08:01,731 --> 00:08:03,441 is just like that. 127 00:08:03,525 --> 00:08:04,775 When a volcano erupts, 128 00:08:04,859 --> 00:08:07,528 underground lava rivers create tubes. 129 00:08:07,612 --> 00:08:09,739 When the lava drains, the tubes remain, 130 00:08:09,823 --> 00:08:11,449 but now they're rock solid. 131 00:08:11,533 --> 00:08:13,117 They become a part of the Earth. 132 00:08:13,201 --> 00:08:15,995 And that means they last forever. 133 00:08:16,079 --> 00:08:17,455 That's what your stem cells will do 134 00:08:17,539 --> 00:08:19,206 to the synthetic trachea 135 00:08:19,290 --> 00:08:23,169 to make it last forever as a part of you. 136 00:08:23,253 --> 00:08:26,047 You're asking my husband to be the first 137 00:08:26,131 --> 00:08:28,841 but offer no guarantee the procedure will work. 138 00:08:28,925 --> 00:08:31,844 No, we cannot offer guarantees 139 00:08:31,928 --> 00:08:34,764 because it would be irresponsible to do so. 140 00:08:34,848 --> 00:08:38,184 Nothing is guaranteed in medicine. 141 00:08:38,268 --> 00:08:39,852 Even just a year ago, 142 00:08:39,936 --> 00:08:43,356 your options would have been much more limited. 143 00:08:43,440 --> 00:08:46,609 You are very lucky to be the first. 144 00:08:46,693 --> 00:08:48,986 Your doctors referred you to us 145 00:08:49,070 --> 00:08:51,989 because the other treatments failed you. 146 00:08:52,073 --> 00:08:55,743 You could have as little as six months to live. 147 00:08:55,827 --> 00:08:59,705 This is your best chance to see your son grow up. 148 00:09:12,969 --> 00:09:14,304 Okay. 149 00:09:16,389 --> 00:09:17,807 Okay. 150 00:09:19,434 --> 00:09:22,436 I think it's very difficult to keep an emotional distance, 151 00:09:22,520 --> 00:09:24,314 especially if it is a child. 152 00:09:26,524 --> 00:09:28,192 Hey. 153 00:09:28,276 --> 00:09:31,195 How you holding up? 154 00:09:31,279 --> 00:09:33,030 I wish I felt numb. 155 00:09:33,114 --> 00:09:35,449 I just feel... 156 00:09:35,533 --> 00:09:37,660 everything. 157 00:09:39,954 --> 00:09:42,165 Give yourself a break, B. 158 00:09:43,958 --> 00:09:47,878 You're not on a schedule here. 159 00:09:47,962 --> 00:09:49,922 It's gonna take what it takes. 160 00:09:50,006 --> 00:09:54,051 You know, with Hannah Warren and John... 161 00:09:54,135 --> 00:09:57,179 it's just a whole lot of death. 162 00:09:57,263 --> 00:09:59,182 How's Lizzi? 163 00:10:01,893 --> 00:10:04,020 She's really quiet. 164 00:10:05,855 --> 00:10:08,357 I think she's pretending to be okay for me, 165 00:10:08,441 --> 00:10:13,112 which makes me feel guilty, which makes me feel worse. 166 00:10:13,196 --> 00:10:16,366 She's just such a daddy's girl. 167 00:10:18,034 --> 00:10:20,286 And that breaks my heart. 168 00:10:20,370 --> 00:10:23,623 At least you still have a heart to break. 169 00:10:23,707 --> 00:10:26,334 Yeah, the pain reminds us we're alive. 170 00:10:26,418 --> 00:10:28,711 It's awesome. 171 00:10:28,795 --> 00:10:30,713 - Work is good? - Work is good. 172 00:10:30,797 --> 00:10:32,632 Work is good. 173 00:10:32,716 --> 00:10:35,176 Hey, how's that piece coming along? 174 00:10:35,260 --> 00:10:37,595 Hey, it's not. 175 00:10:37,679 --> 00:10:39,805 It's... 176 00:10:39,889 --> 00:10:41,766 a special about the future of medicine. 177 00:10:41,850 --> 00:10:43,601 It's supposed to be hopeful. 178 00:10:43,685 --> 00:10:46,562 And now I don't have a story at all. 179 00:10:46,646 --> 00:10:49,774 - What about him? - What about him? 180 00:10:49,858 --> 00:10:51,651 Shift the focus to him, you know? 181 00:10:51,735 --> 00:10:53,194 "Dr. Macchiarini, Miracle Man"-- 182 00:10:53,278 --> 00:10:55,571 a look at the pioneer of generational medicine. 183 00:10:55,655 --> 00:10:57,782 - Regenerative. - Exactly. 184 00:10:57,866 --> 00:10:59,408 But then what about Hannah? 185 00:10:59,492 --> 00:11:03,245 She'd still be part of the main story. 186 00:11:03,329 --> 00:11:05,957 Medical breakthroughs are always paved with setbacks. 187 00:11:06,041 --> 00:11:07,750 It doesn't mean that Macchiarini's work 188 00:11:07,834 --> 00:11:09,460 isn't worth believing in. 189 00:11:11,546 --> 00:11:12,964 Hold on to the hopeful. 190 00:11:13,048 --> 00:11:15,758 If anybody can make it happen, it's you. 191 00:11:39,616 --> 00:11:41,909 When did the pain start? 192 00:11:41,993 --> 00:11:44,453 Um, off and on for the last few weeks. 193 00:11:44,537 --> 00:11:46,872 I just thought it was stress or something. 194 00:11:46,956 --> 00:11:50,293 Would you describe the pain as sharp, dull, or burning? 195 00:11:50,377 --> 00:11:52,753 Sharp, like-- Aah! 196 00:11:52,837 --> 00:11:54,547 Like someone's stabbing me. Ow. 197 00:11:54,631 --> 00:11:56,966 Let's get a CBC, liver enzymes, 198 00:11:57,050 --> 00:11:59,719 urine test, and a CT of the abdomen and pelvis, 199 00:11:59,803 --> 00:12:01,971 plus 30 milligrams of Toradol for the pain. 200 00:12:02,055 --> 00:12:05,099 - So it's my appendix? - It's not your appendix. 201 00:12:05,183 --> 00:12:06,892 What? No, no, no, no, no. 202 00:12:06,976 --> 00:12:08,603 I have a daughter. She's nine years old. 203 00:12:08,687 --> 00:12:10,187 She just lost her father. 204 00:12:10,271 --> 00:12:11,814 I can't have something wrong with me. 205 00:12:11,898 --> 00:12:14,233 We just need to run some tests to see what's going on. 206 00:12:14,317 --> 00:12:15,568 Doctor, they're waiting. 207 00:12:15,652 --> 00:12:17,696 Is there anyone you want to call? 208 00:12:25,328 --> 00:12:27,038 Hi, excuse me. 209 00:12:31,626 --> 00:12:33,544 - Hi. - Hi. 210 00:12:33,628 --> 00:12:35,546 Thank you for coming. I'm sorry. 211 00:12:35,630 --> 00:12:37,715 No, no, I'm glad you called. 212 00:12:37,799 --> 00:12:39,467 - Has the pain subsided? - No. 213 00:12:39,551 --> 00:12:41,260 I think it's worse, actually. 214 00:12:41,344 --> 00:12:42,929 - What did the doctor say? - Nothing. 215 00:12:43,013 --> 00:12:46,599 They just ran a bunch of tests, and no one's told me anything. 216 00:12:46,683 --> 00:12:49,060 I've just been sitting here by myself. 217 00:12:51,980 --> 00:12:54,482 You CT scan shows uterine fibroids. 218 00:12:54,566 --> 00:12:56,609 What? What is that? Is that cancer? 219 00:12:56,693 --> 00:12:59,487 Not at all. They're very common. 220 00:12:59,571 --> 00:13:02,949 - Is it okay if I take a look? - Yeah. 221 00:13:03,033 --> 00:13:04,867 - Yeah? - Okay. 222 00:13:06,661 --> 00:13:08,788 - This might hurt a little bit. - Okay. All right. 223 00:13:08,872 --> 00:13:11,916 Okay. 224 00:13:14,878 --> 00:13:18,047 Yeah, I can feel two. 225 00:13:18,131 --> 00:13:19,799 They're about the size of grapefruits. 226 00:13:19,883 --> 00:13:20,967 What? 227 00:13:21,051 --> 00:13:22,927 It sounds much worse than what it is. 228 00:13:23,011 --> 00:13:25,221 Don't worry. They will have them removed. 229 00:13:25,305 --> 00:13:26,806 So I have to have surgery? 230 00:13:26,890 --> 00:13:28,933 Yeah, but it's a very common procedure. 231 00:13:29,017 --> 00:13:31,978 I'm sure your doctor will walk you through everything. 232 00:13:32,062 --> 00:13:34,397 You're gonna be fine. 233 00:13:34,481 --> 00:13:36,816 Trust me. 234 00:13:48,745 --> 00:13:51,038 He's got you working late already? 235 00:13:51,122 --> 00:13:52,206 I'm preparing. 236 00:13:52,290 --> 00:13:54,208 It's something doctors do. 237 00:13:54,292 --> 00:13:56,502 - You should try it. - Noted. 238 00:13:56,586 --> 00:13:59,130 I'll sleep when I'm published. 239 00:14:02,634 --> 00:14:04,844 Why don't you like him? 240 00:14:04,928 --> 00:14:07,013 I don't really like anybody. 241 00:14:07,097 --> 00:14:08,764 That's true. 242 00:14:08,848 --> 00:14:12,518 Still, so few surgeons want to operate on the throat at all, 243 00:14:12,602 --> 00:14:14,812 and he throws in stem-cell regeneration. 244 00:14:14,896 --> 00:14:17,398 Aren't you interested in his work? 245 00:14:17,482 --> 00:14:20,818 Yes, yes, I find it all very... 246 00:14:20,902 --> 00:14:22,445 interesting. 247 00:14:22,529 --> 00:14:24,447 You're an ass. 248 00:14:24,531 --> 00:14:26,073 Look at this. 249 00:14:26,157 --> 00:14:29,535 He has to identify the surgical planes bordering the trachea, 250 00:14:29,619 --> 00:14:31,704 avoid tumor dissemination, 251 00:14:31,788 --> 00:14:33,539 all without exposing the larynx, 252 00:14:33,623 --> 00:14:35,541 the thyroid, the esophagus. 253 00:14:35,625 --> 00:14:36,876 Say what you want. 254 00:14:36,960 --> 00:14:39,045 Dr. Macchiarini's got some balls. 255 00:14:39,129 --> 00:14:41,881 I guess that's what it takes, huh--some nice big balls? 256 00:14:41,965 --> 00:14:44,008 Sorry, I didn't mean to offend you. 257 00:14:44,092 --> 00:14:46,010 Yes, I have tiny balls. 258 00:14:47,679 --> 00:14:49,805 You know, a good surgeon knows when not to cut. 259 00:14:49,889 --> 00:14:52,350 Fuck that. I'm tired of being on the verge of something. 260 00:14:52,434 --> 00:14:56,228 Too afraid to make the cut-- this is groundbreaking work. 261 00:14:56,312 --> 00:14:58,230 I'm getting in. 262 00:14:58,314 --> 00:15:01,233 Just watch your back. 263 00:15:01,317 --> 00:15:03,194 I always do. 264 00:15:58,166 --> 00:16:00,459 Dr. Svensson. 265 00:16:00,543 --> 00:16:03,296 Dr. Macchiarini? Uh... 266 00:16:07,342 --> 00:16:10,428 Oh, the trials seem to be proceeding nicely. 267 00:16:10,512 --> 00:16:11,596 Uh, yes. 268 00:16:11,680 --> 00:16:14,056 Um, we're on schedule. 269 00:16:14,140 --> 00:16:15,349 Good. 270 00:16:15,433 --> 00:16:18,394 Any exciting conclusions so far? 271 00:16:18,478 --> 00:16:20,313 Well, nothing-- you know, nothing 272 00:16:20,397 --> 00:16:21,981 really determinable yet. 273 00:16:22,065 --> 00:16:24,442 Of course, I won't be able to truly discern 274 00:16:24,526 --> 00:16:26,027 any results until-- 275 00:16:26,111 --> 00:16:28,571 Yeah, until you completed the trials, of course. 276 00:16:28,655 --> 00:16:30,823 - As you can imagine, I'm-- - I'm very anxious 277 00:16:30,907 --> 00:16:33,910 to see any results-- positive or otherwise. 278 00:16:35,537 --> 00:16:36,996 Well, on the test rats 279 00:16:37,080 --> 00:16:38,998 that have received synthetic tracheas, 280 00:16:39,082 --> 00:16:41,000 so far none have responded negatively. 281 00:16:41,084 --> 00:16:42,877 Well, that-- that is excellent. 282 00:16:42,961 --> 00:16:45,171 But as you said, we're still gathering data. 283 00:16:45,255 --> 00:16:47,757 Uh... 284 00:16:47,841 --> 00:16:49,216 the purpose of this trial 285 00:16:49,300 --> 00:16:51,677 is to witness objective results, of course. 286 00:16:51,761 --> 00:16:54,722 Of course, of course. 287 00:16:54,806 --> 00:16:56,807 May I ask, is there anything in particular 288 00:16:56,891 --> 00:16:59,226 - that is concerning you? - Oh, no, not at all. 289 00:16:59,310 --> 00:17:01,687 I have complete faith in your research, Doctor, 290 00:17:01,771 --> 00:17:03,189 as well as my own. 291 00:17:03,273 --> 00:17:04,982 I'll just leave you to your work. 292 00:17:05,066 --> 00:17:06,317 Okay. 293 00:17:06,401 --> 00:17:07,610 Yeah. 294 00:17:28,631 --> 00:17:30,007 - Thank you. - Yeah, no problem. 295 00:17:30,091 --> 00:17:32,802 Oh, thank you, thank you, thank you. 296 00:17:32,886 --> 00:17:34,262 Oh, my God, please. 297 00:17:34,346 --> 00:17:36,973 Wow, I wish I had that effect on you. 298 00:17:37,057 --> 00:17:38,808 48 hours without caffeine? 299 00:17:38,892 --> 00:17:40,352 Who am I today? 300 00:17:43,021 --> 00:17:45,022 I spelled your name for them. 301 00:17:48,193 --> 00:17:50,695 - You're feeling better? - Mm-hmm. 302 00:17:50,779 --> 00:17:53,906 I am. Like two grapefruits lighter. 303 00:17:53,990 --> 00:17:55,700 Thank you, really. 304 00:17:55,784 --> 00:17:57,077 Pleasure. 305 00:18:00,121 --> 00:18:02,707 Paolo... 306 00:18:02,791 --> 00:18:06,210 we've both been through a lot of loss the past few months. 307 00:18:06,294 --> 00:18:09,505 And I know I wasn't dying in there, but I-- 308 00:18:09,589 --> 00:18:11,882 I was really scared, and it... 309 00:18:14,135 --> 00:18:15,886 It just-- 310 00:18:15,970 --> 00:18:18,180 it put things in perspective for me. 311 00:18:18,264 --> 00:18:22,143 Us together, it could cost me my job, my reputation, 312 00:18:22,227 --> 00:18:25,896 but I think this thing we have, it's worth the risk. 313 00:18:27,899 --> 00:18:29,609 For me, too. 314 00:18:34,155 --> 00:18:36,616 You've heard the criticism-- 315 00:18:36,700 --> 00:18:39,660 that you're really taking a chance with these patients. 316 00:18:39,744 --> 00:18:41,704 What do you say to that? 317 00:18:41,788 --> 00:18:44,874 I was raised to believe that if you... 318 00:18:44,958 --> 00:18:48,002 if have even one chance, you need to take it, 319 00:18:48,086 --> 00:18:50,296 because either that patient will die, 320 00:18:50,380 --> 00:18:53,341 or we try to do something, even if it's new. 321 00:18:53,425 --> 00:18:57,303 As a doctor and-- and as a human being, I... 322 00:18:57,387 --> 00:19:01,641 I ask myself, are we allowed to say no? 323 00:19:01,725 --> 00:19:03,267 I don't think we are. 324 00:19:03,351 --> 00:19:05,853 And when you got that call later 325 00:19:05,937 --> 00:19:08,314 - that--that she had passed... - Mm. 326 00:19:08,398 --> 00:19:11,484 It had to be devastating for you. 327 00:19:11,568 --> 00:19:14,028 I couldn't stop thinking... 328 00:19:14,112 --> 00:19:17,198 did I make the right decision? 329 00:19:17,282 --> 00:19:19,533 Did I do everything to save her? 330 00:19:19,617 --> 00:19:22,870 There are so many patients all around the world 331 00:19:22,954 --> 00:19:24,413 who need this procedure. 332 00:19:24,497 --> 00:19:27,333 We should really try to achieve this 333 00:19:27,417 --> 00:19:29,043 for all of them, 334 00:19:29,127 --> 00:19:31,128 because even in the face of failure, 335 00:19:31,212 --> 00:19:33,339 we should keep hope alive. 336 00:19:37,761 --> 00:19:39,428 Great job today, guys. 337 00:19:39,512 --> 00:19:42,223 Dr. Macchiarini, do you mind staying behind 338 00:19:42,307 --> 00:19:44,350 for a few minutes to go over the schedule? 339 00:19:44,434 --> 00:19:45,685 Good night. 340 00:19:48,730 --> 00:19:50,357 Of course. 341 00:19:53,276 --> 00:19:54,568 So? 342 00:19:54,652 --> 00:19:56,153 So... 343 00:19:56,237 --> 00:19:59,448 Well, I have some follow-up questions for you 344 00:19:59,532 --> 00:20:00,533 that are gonna happen... 345 00:20:00,617 --> 00:20:03,828 - Really? - Behind closed doors, yeah. 346 00:20:09,042 --> 00:20:11,878 I'm so sorry you had to go through this. 347 00:20:13,630 --> 00:20:15,464 It's okay. 348 00:20:15,548 --> 00:20:18,175 It's just gonna be a scar. 349 00:20:18,259 --> 00:20:19,677 One day we will live in a world 350 00:20:19,761 --> 00:20:22,597 where we won't have to cut people open to fix them. 351 00:20:22,681 --> 00:20:24,224 You'll see. 352 00:20:26,935 --> 00:20:30,313 Do you ever have any doubts? 353 00:20:30,397 --> 00:20:31,606 Of course I do. 354 00:20:31,690 --> 00:20:34,025 - Really? - Mm-hmm. 355 00:20:34,109 --> 00:20:37,237 'Cause you seem so sure of all of it. 356 00:20:39,030 --> 00:20:41,449 Even the things that could go wrong, 357 00:20:41,533 --> 00:20:44,160 that have gone wrong... 358 00:20:44,244 --> 00:20:47,330 you just keep moving forward. 359 00:20:47,414 --> 00:20:50,417 I think a lot about the ones who came before me. 360 00:20:52,669 --> 00:20:55,004 Like Thomas Starzl-- 361 00:20:55,088 --> 00:20:57,882 he started the first liver transplants. 362 00:20:57,966 --> 00:21:00,676 - His first patients died. - Hmm. 363 00:21:00,760 --> 00:21:03,304 Or Christiaan Barnard... 364 00:21:03,388 --> 00:21:06,557 he performed the first heart transplant. 365 00:21:06,641 --> 00:21:08,893 People threw rocks at him. 366 00:21:08,977 --> 00:21:12,480 Everybody thought he was crazy. 367 00:21:12,564 --> 00:21:14,482 I'm sure people looked at him the same way 368 00:21:14,566 --> 00:21:16,442 that you're looking at me right now. 369 00:21:21,322 --> 00:21:24,784 When Hannah died, I did lose faith. 370 00:21:24,868 --> 00:21:27,078 But these doctors, they-- 371 00:21:27,162 --> 00:21:30,706 they believed, they worked, they persevered 372 00:21:30,790 --> 00:21:32,833 until they found their way. 373 00:21:32,917 --> 00:21:34,877 Being the one to try something new, 374 00:21:34,961 --> 00:21:36,337 no matter the personal cost, 375 00:21:36,421 --> 00:21:38,756 is vital to move medicine forward. 376 00:21:38,840 --> 00:21:41,300 It's vital. 377 00:21:41,384 --> 00:21:43,761 And I believe that the work that we're doing 378 00:21:43,845 --> 00:21:47,139 is going to save many lives. 379 00:21:47,223 --> 00:21:49,475 I believe it will, too. 380 00:22:03,406 --> 00:22:06,575 Hi, my love. I'm here, missing you in Barcelona. 381 00:22:06,659 --> 00:22:08,619 The lemon trees are ready for you. 382 00:22:08,703 --> 00:22:12,206 Oh, there is a sushi roll with my name on it. 383 00:22:12,290 --> 00:22:14,875 - Benita? - Hmm? Oh, yeah, lunch. 384 00:22:14,959 --> 00:22:16,669 - You ready? - Sorry. Yeah. 385 00:22:16,753 --> 00:22:17,878 Good. 386 00:22:30,141 --> 00:22:32,143 - Mm. - Come on, come on... 387 00:22:40,485 --> 00:22:42,528 No, I hear you. The information is great. 388 00:22:42,612 --> 00:22:44,280 But I'm going to need another source on it 389 00:22:44,364 --> 00:22:47,033 to confirm her account. 390 00:22:47,117 --> 00:22:49,076 Sure. Could you email that to me? 391 00:22:49,160 --> 00:22:51,370 Wow, that sounds good. 392 00:22:51,454 --> 00:22:52,955 Yeah. 393 00:22:53,039 --> 00:22:55,041 - It's Lizzi. Okay. - I'll miss you. 394 00:22:55,125 --> 00:22:57,209 Yeah. Sure. 395 00:22:57,293 --> 00:22:58,711 It's okay with me. 396 00:22:58,795 --> 00:23:01,797 If it's okay with Aubrey's mom, you can sleep over. 397 00:23:01,881 --> 00:23:05,426 Okay. I love you, too. Bye. 398 00:23:05,510 --> 00:23:07,595 - Did you say "sleep over"? - Yeah. 399 00:23:07,679 --> 00:23:10,056 Maybe I could change my flight. 400 00:23:10,140 --> 00:23:12,350 Oh, I didn't know that was an option. 401 00:23:12,434 --> 00:23:13,768 Mm-hmm. 402 00:23:20,900 --> 00:23:22,944 - What? - The Stones are sexier. 403 00:23:23,028 --> 00:23:24,445 - No, no, no. - That's it. 404 00:23:24,529 --> 00:23:27,406 How can you even compare them? 405 00:23:27,490 --> 00:23:29,784 I've always thought this, and I'm not going to apologize. 406 00:23:29,868 --> 00:23:31,160 "Blackbird," um... 407 00:23:31,244 --> 00:23:32,620 "Martha My Dear," 408 00:23:32,704 --> 00:23:34,956 "While My Guitar Gently Weeps," "Rocky Raccoon." 409 00:23:35,040 --> 00:23:36,290 Okay, now we're listing songs? 410 00:23:36,374 --> 00:23:38,000 - Yeah. - "Satisfaction"... 411 00:23:38,084 --> 00:23:39,919 - Oh. - "Gimme Shelter," 412 00:23:40,003 --> 00:23:41,629 - "Sympathy for the Devil." - No. 413 00:23:41,713 --> 00:23:43,464 No, we can't have this conversation. 414 00:23:43,548 --> 00:23:45,675 This is terrible. Now I have to leave you. 415 00:23:45,759 --> 00:23:47,301 - Are you gonna leave me? - I'm gonna leave you. 416 00:23:47,385 --> 00:23:48,719 Are you gonna leave me for The Beatles? 417 00:23:48,803 --> 00:23:50,388 - This is a very, very... - They're almost-- 418 00:23:50,472 --> 00:23:52,431 - All of them are dead, almost. - Important distinction. 419 00:23:59,356 --> 00:24:02,024 Italian "Vogue," nice touch. 420 00:24:02,108 --> 00:24:04,277 - For Lizzi. - Ah. 421 00:24:06,404 --> 00:24:10,324 Hey, Lizzi? My friend Paolo is here. 422 00:24:10,408 --> 00:24:13,828 - Your "friend"? - My friend. 423 00:24:23,380 --> 00:24:26,173 "Cacio" means "cheese," 424 00:24:26,257 --> 00:24:30,094 and "pepe" means "pepper." 425 00:24:30,178 --> 00:24:32,346 So it's like Italian mac and cheese. 426 00:24:34,099 --> 00:24:36,726 And pepper, you know, "pepe." 427 00:24:36,810 --> 00:24:38,644 It's delicious, right? 428 00:24:38,728 --> 00:24:41,314 What do you think, kiddo? 429 00:24:41,398 --> 00:24:43,441 I don't like it. 430 00:24:48,321 --> 00:24:50,531 Your mom tells me that you play the violin. 431 00:24:50,615 --> 00:24:52,074 - She does, yeah. - Yeah? 432 00:24:52,158 --> 00:24:53,534 She practices every day. 433 00:24:53,618 --> 00:24:55,494 Sometimes I don't even have to ask her to practice. 434 00:24:55,578 --> 00:24:57,663 Oh, wow. That's impressive. 435 00:24:57,747 --> 00:24:59,081 It's impressive, 436 00:24:59,165 --> 00:25:02,209 'cause I used to play the piano when I was your age, 437 00:25:02,293 --> 00:25:04,337 but I hated to practice. 438 00:25:04,421 --> 00:25:05,880 Well, maybe we can play together. 439 00:25:05,964 --> 00:25:08,215 You--you play the violin, and I play the piano. 440 00:25:08,299 --> 00:25:10,551 We make a concert for your mom. 441 00:25:13,513 --> 00:25:14,847 Mm. 442 00:25:14,931 --> 00:25:17,725 Did you hear what happened when Johann Sebastian Bach 443 00:25:17,809 --> 00:25:19,769 dropped his violin? 444 00:25:19,853 --> 00:25:21,896 It Baroque. 445 00:25:21,980 --> 00:25:23,814 It Ba-roque. 446 00:25:23,898 --> 00:25:25,733 Ba-roque, that's funny. 447 00:25:25,817 --> 00:25:29,236 - Can I go to my room? - Lizzi, come on, please. 448 00:25:29,320 --> 00:25:31,948 No, it's okay. 449 00:25:32,032 --> 00:25:34,575 But, Lizzi... 450 00:25:34,659 --> 00:25:38,663 I know that you're feeling a thousand things right now, 451 00:25:38,747 --> 00:25:39,997 all at once. 452 00:25:40,081 --> 00:25:42,959 And I'm ready to wait for as long as it takes 453 00:25:43,043 --> 00:25:46,045 for you to figure out how you feel about me. 454 00:25:46,129 --> 00:25:47,713 But I'll make you a deal. 455 00:25:47,797 --> 00:25:49,590 If you let me show you 456 00:25:49,674 --> 00:25:52,802 how much I care about your mom, 457 00:25:52,886 --> 00:25:55,763 I promise you I will never make you eat 458 00:25:55,847 --> 00:25:58,599 my cacio e pepe again. 459 00:25:58,683 --> 00:26:00,518 Accordo? 460 00:26:04,022 --> 00:26:05,147 Accordo. 461 00:26:07,442 --> 00:26:10,611 Good night. 462 00:26:13,531 --> 00:26:16,367 She'll get there. 463 00:26:16,451 --> 00:26:17,952 It takes time. 464 00:26:20,413 --> 00:26:21,622 It's really good. 465 00:26:21,706 --> 00:26:22,915 But you got it, right, Baroque? 466 00:26:22,999 --> 00:26:23,958 - I got Baroque. - Okay. 467 00:26:24,042 --> 00:26:25,960 Yeah, it's a cute joke. 468 00:26:32,884 --> 00:26:36,929 Hey, three more pages, then jammies and lights out, okay? 469 00:26:37,013 --> 00:26:38,598 Okay. 470 00:26:41,559 --> 00:26:44,020 - I love you. - I love you, too. 471 00:26:44,104 --> 00:26:45,813 Good night. 472 00:26:45,897 --> 00:26:47,231 Hey, Mom? 473 00:26:49,359 --> 00:26:51,652 I like his accent. 474 00:27:05,041 --> 00:27:07,126 What? Are you kidding me? You cooked. 475 00:27:07,210 --> 00:27:08,336 Get out of here. 476 00:27:16,052 --> 00:27:17,929 What? 477 00:27:18,013 --> 00:27:20,181 I have bad news. 478 00:27:20,265 --> 00:27:22,475 - Our trip to Barcelona-- - No! 479 00:27:22,559 --> 00:27:24,894 - I have to cancel. - Oh. 480 00:27:24,978 --> 00:27:27,021 Uh, there's-- there's a new patient 481 00:27:27,105 --> 00:27:28,898 I need to meet in Moscow. 482 00:27:28,982 --> 00:27:31,525 I was so looking forward to finally seeing your place. 483 00:27:31,609 --> 00:27:33,361 I know, my love, and I'm so sorry, 484 00:27:33,445 --> 00:27:34,737 but if she agrees to surgery, 485 00:27:34,821 --> 00:27:36,989 this could launch funding for the entire lab. 486 00:27:37,073 --> 00:27:38,449 No, I-I get it, I get it. 487 00:27:38,533 --> 00:27:41,619 I just, um... 488 00:27:41,703 --> 00:27:44,372 have to figure out what to tell Kim and everybody else, 489 00:27:44,456 --> 00:27:46,040 'cause I already took time off. 490 00:27:46,124 --> 00:27:48,209 And I have Laura coming to stay with Lizzi and-- 491 00:27:48,293 --> 00:27:50,336 Why don't you come with me? 492 00:27:50,420 --> 00:27:52,546 - To Russia? - To Moscow. 493 00:27:52,630 --> 00:27:54,883 I can show you off in Moscow. 494 00:27:56,468 --> 00:27:57,885 I don't know. 495 00:27:57,969 --> 00:28:00,054 Oh, come on, Benita, I want to spend time with you 496 00:28:00,138 --> 00:28:01,931 without having to hide--please. 497 00:28:02,015 --> 00:28:04,767 We have to wait until the special airs 498 00:28:04,851 --> 00:28:06,560 before we tell anybody anything. 499 00:28:06,644 --> 00:28:09,105 I'm sure our secret will be safe in Russia. 500 00:28:09,189 --> 00:28:10,815 Please come with me. 501 00:28:10,899 --> 00:28:13,317 - Please, come with me. - Okay. 502 00:28:13,401 --> 00:28:14,986 I mean, who-- 503 00:28:15,070 --> 00:28:19,031 who am I to say no to the great Dr. Macchiarini. 504 00:28:30,210 --> 00:28:32,378 Accessing the cricoid ring. 505 00:28:39,678 --> 00:28:42,513 I see severe infection, most likely caused 506 00:28:42,597 --> 00:28:45,391 by the excessive radiation treatments on the patient. 507 00:28:45,475 --> 00:28:47,435 The cartilage is necrotic. 508 00:28:47,519 --> 00:28:49,312 If the tumor hadn't killed him, 509 00:28:49,396 --> 00:28:50,938 it would have been only a matter of time 510 00:28:51,022 --> 00:28:53,107 before he succumbed to infection. 511 00:28:57,779 --> 00:28:59,113 Knife. 512 00:29:02,575 --> 00:29:04,493 Starting resection. 513 00:29:04,577 --> 00:29:08,581 The biosynthetic trachea will fit perfectly 514 00:29:08,665 --> 00:29:10,124 in the resected area. 515 00:29:37,569 --> 00:29:38,945 Metzenbaum. 516 00:29:56,504 --> 00:29:58,214 Okay. 517 00:30:21,613 --> 00:30:25,199 Okay, switch the oxygen input. 518 00:30:30,246 --> 00:30:31,956 Saline. 519 00:30:32,040 --> 00:30:35,459 Any leaks in the trachea will produce bubbles in the saline. 520 00:30:38,588 --> 00:30:40,339 Pulse ox? 521 00:30:40,423 --> 00:30:42,216 Holding steady. 522 00:30:45,136 --> 00:30:47,054 No signs of leaking. 523 00:30:47,138 --> 00:30:50,850 Oxygen holding, 98%. 524 00:30:52,185 --> 00:30:53,561 It's working. 525 00:30:53,645 --> 00:30:56,230 Congratulations, Doctor. 526 00:30:56,314 --> 00:30:58,774 Okay, let's close him up. 527 00:30:58,858 --> 00:31:01,068 Doctor? 528 00:31:01,152 --> 00:31:02,445 BP's dropping. 529 00:31:02,529 --> 00:31:04,488 - He's bleeding. - Vitals are weakening. 530 00:31:04,572 --> 00:31:06,407 No, it can't be. The implant is working. 531 00:31:06,491 --> 00:31:08,701 Where is this blood coming from? 532 00:31:08,785 --> 00:31:10,911 Doctor? 533 00:31:10,995 --> 00:31:12,830 The left carotid's most likely ruptured. 534 00:31:12,914 --> 00:31:14,582 No, I didn't touch it. I wasn't even near it. 535 00:31:14,666 --> 00:31:16,042 You said there was radiation damage. 536 00:31:16,126 --> 00:31:17,251 Losing OX. 537 00:31:17,335 --> 00:31:18,920 It must have weakened the vascular wall. 538 00:31:19,004 --> 00:31:20,588 - Doctor. - Blood pressure is dropping. 539 00:31:20,672 --> 00:31:22,256 Doctor, we need to do something. 540 00:31:22,340 --> 00:31:23,466 - Doctor? - Losing oxygen. 541 00:31:23,550 --> 00:31:25,009 Doctor? 542 00:31:25,093 --> 00:31:26,510 Paolo! 543 00:31:26,594 --> 00:31:29,597 I can fix this. 544 00:31:29,681 --> 00:31:31,766 He needs to be stabilized. 545 00:31:34,227 --> 00:31:37,313 - Suction? - Blood pressure is dropping. 546 00:31:42,819 --> 00:31:44,695 Found it. Cautery. 547 00:31:58,793 --> 00:32:02,088 BP is on the rise. 548 00:32:02,172 --> 00:32:03,923 He's stable. 549 00:32:04,007 --> 00:32:07,176 Sutures for Dr. Macchiarini. 550 00:32:07,260 --> 00:32:09,596 You should close him. 551 00:32:47,467 --> 00:32:50,219 All right, my love, this way. 552 00:32:50,303 --> 00:32:51,721 I was texting with Lizzi 553 00:32:51,805 --> 00:32:53,639 about setting up our Skype call. 554 00:32:53,723 --> 00:32:54,974 Mm-hmm? 555 00:32:55,058 --> 00:32:57,059 And she specifically asked for you to jump on. 556 00:32:57,143 --> 00:32:58,644 - Oh, she did? - Yeah. 557 00:32:58,728 --> 00:33:00,855 You charmed her, you big charmer. 558 00:33:09,406 --> 00:33:11,657 Pardon me. 559 00:33:11,741 --> 00:33:14,076 Uh, compliments of the gentleman at the bar. 560 00:33:19,958 --> 00:33:21,334 Thank you. 561 00:33:23,461 --> 00:33:27,715 To you, to me, and to ice buckets, always. 562 00:33:27,799 --> 00:33:29,676 Cheers. 563 00:33:33,013 --> 00:33:35,681 So who is our benefactor this evening? 564 00:33:35,765 --> 00:33:38,100 - I shouldn't say. - Paolo, come on. 565 00:33:38,184 --> 00:33:40,520 I protect sources for a living. 566 00:33:42,647 --> 00:33:45,942 He's a Russian oligarch, very connected. 567 00:33:46,026 --> 00:33:48,319 No, don't look. 568 00:33:48,403 --> 00:33:50,780 There is a network of high-profile patients, 569 00:33:50,864 --> 00:33:53,741 celebrities, clergy, presidents 570 00:33:53,825 --> 00:33:57,203 that are treated in secret, that I treat in secret. 571 00:33:57,287 --> 00:33:58,621 Because of who they are, 572 00:33:58,705 --> 00:34:01,749 I have to keep our arrangement quiet. 573 00:34:01,833 --> 00:34:06,003 Presidents, like U.S. presidents? 574 00:34:07,797 --> 00:34:11,676 Paolo Macchiarini, surgeon to the stars? 575 00:34:11,760 --> 00:34:14,303 Okay. 576 00:34:14,387 --> 00:34:16,555 I--Somebody's got to do it, right? 577 00:34:16,639 --> 00:34:18,725 - Shh, they're coming. - Oh. 578 00:34:21,436 --> 00:34:24,522 Yulia, this is Benita Alexander. 579 00:34:24,606 --> 00:34:27,942 - Paolo, good to see you. - It's nice to meet you. 580 00:34:29,402 --> 00:34:32,196 If you're trying to impress me, Doctor, 581 00:34:32,280 --> 00:34:33,531 it's--it's working. 582 00:34:33,615 --> 00:34:35,908 Yulia, my dear, for you, only the best. 583 00:34:35,992 --> 00:34:38,995 Uh, Paolo tells me you're a dancer. 584 00:34:39,079 --> 00:34:41,330 The best in Russia. 585 00:34:41,414 --> 00:34:44,792 I met Andrej not long after I joined the Bolshoi. 586 00:34:44,876 --> 00:34:46,377 I saw her perform in "Swan Lake." 587 00:34:46,461 --> 00:34:48,170 She was magnificent. 588 00:34:48,254 --> 00:34:50,840 I was only part of the corps de ballet, not the soloist. 589 00:34:50,924 --> 00:34:53,175 Still, I could not take my eyes off of her. 590 00:34:54,678 --> 00:34:57,471 While I was on tour in London a few years ago, 591 00:34:57,555 --> 00:35:01,559 I was involved in a horrible car accident. 592 00:35:01,643 --> 00:35:03,519 It's a miracle she's even alive. 593 00:35:03,603 --> 00:35:05,646 My windpipe was broken. My... 594 00:35:05,730 --> 00:35:07,481 Everything was broken. 595 00:35:07,565 --> 00:35:10,443 And it left me with this hole in my neck. 596 00:35:10,527 --> 00:35:11,986 I'm so sorry. 597 00:35:12,070 --> 00:35:15,698 The past is a lighthouse, not a port. 598 00:35:15,782 --> 00:35:19,243 I found Dr. Macchiarini. 599 00:35:19,327 --> 00:35:22,538 Up until now, we have implanted 600 00:35:22,622 --> 00:35:24,498 only patients for compassionate use, 601 00:35:24,582 --> 00:35:27,209 those who otherwise would die. 602 00:35:27,293 --> 00:35:30,713 But you have shown me that quality of life 603 00:35:30,797 --> 00:35:33,883 is nearly as important as life itself. 604 00:35:33,967 --> 00:35:36,719 So this is an elective surgery? 605 00:35:36,803 --> 00:35:38,846 - Yeah. - Mm. 606 00:35:38,930 --> 00:35:41,140 A part of me 607 00:35:41,224 --> 00:35:45,895 hopes it will allow me to dance again, but, mostly... 608 00:35:45,979 --> 00:35:49,565 we have a two-year-old son, Sasha. 609 00:35:49,649 --> 00:35:52,234 I want to play with him... 610 00:35:52,318 --> 00:35:54,070 Sing him a lullaby. 611 00:35:54,154 --> 00:35:56,113 And you're the perfect candidate. 612 00:35:56,197 --> 00:35:58,282 You're young, healthy, 613 00:35:58,366 --> 00:36:01,077 no other medical issues that would complicate matters. 614 00:36:01,161 --> 00:36:03,245 You-- you're ready. 615 00:36:03,329 --> 00:36:05,247 Mm. I really don't want to go to Sweden. 616 00:36:05,331 --> 00:36:09,919 I wish you were set up to operate in Russia. 617 00:36:10,003 --> 00:36:13,089 Then I have great news for you. 618 00:36:13,173 --> 00:36:15,716 Our colleague, Dr. Lasbrey, is setting up facilities 619 00:36:15,800 --> 00:36:18,386 in Krasnodar as we speak. 620 00:36:18,470 --> 00:36:21,764 Your procedure will launch our work here in Russia, Yulia. 621 00:36:21,848 --> 00:36:24,934 You will have your operation here. 622 00:36:29,022 --> 00:36:31,274 - To Dr. Paolo Macchiarini... - Ah. 623 00:36:31,358 --> 00:36:33,567 Our rock-star surgeon. 624 00:36:38,948 --> 00:36:41,325 Mm. 625 00:36:41,409 --> 00:36:42,952 - You okay? - Mm-hmm. 626 00:36:43,036 --> 00:36:44,704 - Yeah? - Yeah, I'm okay. 627 00:36:50,210 --> 00:36:53,045 This ballet was first performed in 1871. 628 00:36:53,129 --> 00:36:54,714 You know-- 629 00:36:54,798 --> 00:36:57,174 Are you okay? 630 00:36:57,258 --> 00:36:59,468 Hey. Hey, hey, hey, my love. 631 00:36:59,552 --> 00:37:02,680 Hey, are you okay? 632 00:37:02,764 --> 00:37:04,724 I'm sorry. I don't think I can-- 633 00:37:04,808 --> 00:37:06,809 No, no, no, we'll go home. No, we'll go. I text you. 634 00:37:06,893 --> 00:37:08,644 No, she's-- I'll text you, okay? 635 00:37:08,728 --> 00:37:10,479 - Let's go. - Are you sure? Should I-- 636 00:37:10,563 --> 00:37:11,731 Yes. Yeah, yeah. 637 00:37:14,693 --> 00:37:16,027 You're getting worse. 638 00:37:16,111 --> 00:37:17,987 You should have let me take you to the hospital. 639 00:37:18,071 --> 00:37:20,239 No, I just want to lie down. 640 00:37:23,785 --> 00:37:27,330 - You're burning up. - Mm. I feel sick. 641 00:37:27,414 --> 00:37:29,082 Let me check something. 642 00:37:31,751 --> 00:37:33,794 The surgical site is infected. 643 00:37:33,878 --> 00:37:35,880 What? There's no way. That was months ago. 644 00:37:35,964 --> 00:37:38,716 - It's got to be healed by now. - No, it's not. 645 00:37:46,766 --> 00:37:49,727 So--so what, antibiotics or something? 646 00:37:49,811 --> 00:37:52,355 No, it's too late for that. 647 00:37:52,439 --> 00:37:56,150 You're in sepsis. I need to debride your wound. 648 00:37:56,234 --> 00:37:57,944 Otherwise, you will go into shock. 649 00:37:58,028 --> 00:38:00,863 "Debride"? What does that mean? 650 00:38:00,947 --> 00:38:03,199 You're gonna be okay. 651 00:38:06,703 --> 00:38:08,371 Do you trust me? 652 00:38:11,708 --> 00:38:13,376 Mm-hmm. 653 00:38:42,447 --> 00:38:43,990 "Two months after transplantation, 654 00:38:44,074 --> 00:38:45,700 "the patient is asymptomatic, 655 00:38:45,784 --> 00:38:48,577 "breathes normally, and is tumor free. 656 00:38:48,661 --> 00:38:50,204 "These results are evidence 657 00:38:50,288 --> 00:38:53,332 "that a successful organ-regeneration strategy 658 00:38:53,416 --> 00:38:55,376 has been accomplished." 659 00:38:55,460 --> 00:38:59,005 "And the procedure's success provides proof 660 00:38:59,089 --> 00:39:00,965 of the viability of this approach." 661 00:39:02,509 --> 00:39:05,469 To Dr. Macchiarini, who dared to make the cut. 662 00:39:05,553 --> 00:39:06,679 Cheers. 663 00:39:06,763 --> 00:39:08,180 To Andemariam Beyene, 664 00:39:08,264 --> 00:39:11,142 who bravely risked his life for science. 665 00:39:11,226 --> 00:39:12,351 Cheers. 666 00:39:12,435 --> 00:39:13,936 And last but not least, 667 00:39:14,020 --> 00:39:16,022 to The motherfucking "Lancet" 668 00:39:16,106 --> 00:39:18,691 for publishing our research article. 669 00:39:18,775 --> 00:39:21,277 - Cheers! - Skol, Anders. 670 00:39:21,361 --> 00:39:24,030 Nathan, tack. 671 00:39:24,114 --> 00:39:25,948 So published in "The Lancet"-- 672 00:39:26,032 --> 00:39:28,659 you're halfway to a Nobel. 673 00:39:28,743 --> 00:39:30,119 This is shit. 674 00:39:30,203 --> 00:39:32,204 You'd think they would have sprung for better bubbly. 675 00:39:32,288 --> 00:39:35,166 Then feel free to steal someone else's. 676 00:39:35,250 --> 00:39:38,044 - Fantastic. - Cheers. 677 00:39:38,128 --> 00:39:39,921 I'm surprised to see you here, 678 00:39:40,005 --> 00:39:41,839 knowing how you feel about Dr. Macchiarini. 679 00:39:41,923 --> 00:39:43,716 Well, free champagne is free champagne-- 680 00:39:43,800 --> 00:39:45,051 - or whatever this is. - Of course. 681 00:39:45,135 --> 00:39:47,929 You must all be on cloud nine. 682 00:39:48,013 --> 00:39:49,221 I'm excited, of course, 683 00:39:49,305 --> 00:39:50,932 though I also have the feeling of-- 684 00:39:51,016 --> 00:39:53,184 What do you call it? Impostor's syndrome. 685 00:39:53,268 --> 00:39:54,310 Why? 686 00:39:54,394 --> 00:39:56,062 You're running Macchiarini's rat trials. 687 00:39:56,146 --> 00:39:58,981 Which are still in progress. 688 00:39:59,065 --> 00:40:01,359 Macchiarini included my name in the byline, 689 00:40:01,443 --> 00:40:04,946 but I have yet to submit my results. 690 00:40:05,030 --> 00:40:07,406 Welcome to the world of scientific publishing. 691 00:40:07,490 --> 00:40:09,575 As I recall someone once saying, 692 00:40:09,659 --> 00:40:11,911 "Competition fuels progress." 693 00:40:44,611 --> 00:40:45,987 - Okay. - Here we go. 694 00:40:46,071 --> 00:40:47,989 Watch out for the chair. 695 00:40:48,073 --> 00:40:50,241 Yeah, but I can't watch anything. 696 00:40:50,325 --> 00:40:51,701 Okay. 697 00:40:51,785 --> 00:40:54,412 - Okay, you can open your eyes. - No. 698 00:40:54,496 --> 00:40:56,998 You said you wanted to start playing again. 699 00:40:57,082 --> 00:40:58,916 - We can do a duet. - Wow. 700 00:40:59,000 --> 00:41:01,002 Yeah, we can do a duet. 701 00:41:01,086 --> 00:41:02,837 This is incredible. Thank you. 702 00:41:02,921 --> 00:41:04,672 - Careful with your stitches. - Aw. 703 00:41:04,756 --> 00:41:06,424 Love, come here. 704 00:41:06,508 --> 00:41:09,260 Thank you so much. Wow, this is so cool. 705 00:41:09,344 --> 00:41:11,345 But first, I have to remember how to play. 706 00:41:11,429 --> 00:41:13,723 - Oh, let me get my phone. - This is so cool. 707 00:41:13,807 --> 00:41:16,350 Thank you. 708 00:41:33,243 --> 00:41:36,287 ♪ Knowing I'll be missing ♪ 709 00:41:36,371 --> 00:41:40,875 ♪ Christmas Eve in my hometown ♪ 710 00:41:40,959 --> 00:41:43,961 - Thank you. - Mm. 711 00:41:44,045 --> 00:41:45,713 Are you okay? 712 00:41:45,797 --> 00:41:48,883 Yeah. Christmas, family... 713 00:41:48,967 --> 00:41:51,510 holidays, you know? 714 00:41:51,594 --> 00:41:53,888 It makes you sad? 715 00:41:53,972 --> 00:41:56,599 Not really, not this year. 716 00:41:56,683 --> 00:41:58,518 We feel like a family. 717 00:42:00,979 --> 00:42:03,689 You read my mind. 718 00:42:03,773 --> 00:42:05,024 Lizzi. 719 00:42:07,444 --> 00:42:08,736 Wait. Hold on. 720 00:42:08,820 --> 00:42:11,989 What--what is going on? This feels like collusion. 721 00:42:16,786 --> 00:42:19,413 ♪ Through dreams and just pretending ♪ 722 00:42:19,497 --> 00:42:23,251 ♪ I'm there, and I'll be spending ♪ 723 00:42:23,335 --> 00:42:26,504 ♪ Christmas Eve in my hometown ♪ 724 00:42:26,588 --> 00:42:28,548 What do you say, Mom? 725 00:42:30,550 --> 00:42:32,093 What do you say? 726 00:42:32,177 --> 00:42:35,346 ♪ In my hometown ♪ 727 00:42:47,192 --> 00:42:49,110 - Hey, come in. - Hello. 728 00:42:49,194 --> 00:42:51,570 Hi. Please come in. 729 00:42:51,654 --> 00:42:53,739 Look... 730 00:42:53,823 --> 00:42:57,201 Mr. Beyene sent it. 731 00:42:57,285 --> 00:42:58,745 Oh. 732 00:43:03,041 --> 00:43:06,127 - It's nice, isn't it? - Yeah. 733 00:43:06,211 --> 00:43:08,713 I wish our work always ended like that. 734 00:43:08,797 --> 00:43:10,965 Yes. 735 00:43:11,049 --> 00:43:13,134 Thank you for sharing that with me. 736 00:43:13,218 --> 00:43:15,970 Sometimes it's nice to be reminded why we-- 737 00:43:16,054 --> 00:43:18,889 Sacrifice. 738 00:43:18,973 --> 00:43:20,600 So you, too? 739 00:43:20,684 --> 00:43:24,312 Oh, you know, nothing big-- just girlfriends, children, 740 00:43:24,396 --> 00:43:26,105 probably a few years off my life. 741 00:43:26,189 --> 00:43:29,150 Well, maybe we can build something together 742 00:43:29,234 --> 00:43:32,069 that will make it all worthwhile. 743 00:43:32,153 --> 00:43:33,947 I think we can. 744 00:43:35,740 --> 00:43:37,783 The funding for our transplant research 745 00:43:37,867 --> 00:43:39,327 is about to run out. 746 00:43:39,411 --> 00:43:41,829 I'm sure "The Lancet" article garnered some attention. 747 00:43:41,913 --> 00:43:43,831 Yes, we can capitalize on that momentum 748 00:43:43,915 --> 00:43:45,791 to secure a new grant, 749 00:43:45,875 --> 00:43:48,127 which will lead to more surgeries 750 00:43:48,211 --> 00:43:50,796 and to more money. 751 00:43:50,880 --> 00:43:53,132 Around and around. 752 00:43:53,216 --> 00:43:55,635 Until we can expand... 753 00:43:55,719 --> 00:43:58,012 globally. 754 00:43:58,096 --> 00:44:01,432 The goal is six operations within the next three months. 755 00:44:03,893 --> 00:44:08,022 You can produce that many custom tracheas in that time? 756 00:44:08,106 --> 00:44:11,192 Yes, it can be done. 757 00:44:11,276 --> 00:44:13,945 But we need more patients. 758 00:44:14,029 --> 00:44:16,489 Then let's find more patients.