1 00:00:10,927 --> 00:00:13,638 [tense music] 2 00:00:13,722 --> 00:00:15,681 - I read this piece in "The Times" 3 00:00:15,765 --> 00:00:17,683 about this little girl who needs a new windpipe. 4 00:00:17,767 --> 00:00:19,477 Name's Hannah Warren. 5 00:00:19,561 --> 00:00:21,103 Her family's working with this doctor in Europe. 6 00:00:21,187 --> 00:00:23,272 - Dr. Paolo Macchiarini. 7 00:00:23,356 --> 00:00:25,816 - The focus of my research is tracheal transplants 8 00:00:25,900 --> 00:00:27,693 with the help of stem cells 9 00:00:27,777 --> 00:00:31,030 by developing biosynthetic tracheas. 10 00:00:31,114 --> 00:00:32,531 - So you're basically tricking the body 11 00:00:32,615 --> 00:00:34,325 into thinking the implant's already a part of you. 12 00:00:34,409 --> 00:00:36,661 - Will you be interested in assisting? 13 00:00:36,745 --> 00:00:37,995 - Yes. Yes. 14 00:00:38,079 --> 00:00:39,622 - I was wondering if you would be interested 15 00:00:39,706 --> 00:00:42,208 in collaborating on rat trials to test our tracheas. 16 00:00:42,292 --> 00:00:44,252 - Absolutely. - Welcome to the team. 17 00:00:44,336 --> 00:00:46,254 - So this is the first artificial-trachea transplant 18 00:00:46,338 --> 00:00:48,005 in the U.S., 19 00:00:48,089 --> 00:00:50,758 and I want Hannah's journey to be the focus of the piece. 20 00:00:50,842 --> 00:00:52,134 - Surgery went well. 21 00:00:52,218 --> 00:00:54,845 - I have watched you for a while now. 22 00:00:54,929 --> 00:00:56,722 What you did, it was a miracle. 23 00:00:56,806 --> 00:01:00,518 - [chuckles] - Paolo, I shouldn't. 24 00:01:00,602 --> 00:01:02,770 - The science doesn't seem sound. 25 00:01:02,854 --> 00:01:04,563 - It's not exactly your kind of science. 26 00:01:04,647 --> 00:01:08,401 - I will admit I don't get it. 27 00:01:08,485 --> 00:01:09,694 - Knife. 28 00:01:09,778 --> 00:01:12,405 After the operation, she's healthy and happy 29 00:01:12,489 --> 00:01:13,782 with her donor trachea. 30 00:01:19,412 --> 00:01:21,372 [person coughing] 31 00:01:21,456 --> 00:01:24,750 [foreboding music] 32 00:01:24,834 --> 00:01:27,712 [coughing continues] 33 00:01:27,796 --> 00:01:34,719 ♪ ♪ 34 00:01:47,399 --> 00:01:50,318 [monitor beeping] 35 00:01:50,402 --> 00:01:57,534 ♪ ♪ 36 00:02:14,968 --> 00:02:17,929 [no audio] 37 00:02:18,013 --> 00:02:24,936 ♪ ♪ 38 00:02:25,020 --> 00:02:27,980 [monitor flatlining] 39 00:02:28,064 --> 00:02:35,196 ♪ ♪ 40 00:02:36,281 --> 00:02:40,535 [alarm blaring] 41 00:02:46,708 --> 00:02:49,794 - Hannah Warren will be the youngest patient 42 00:02:49,878 --> 00:02:53,047 ever to receive a biosynthetic tracheal transplant. 43 00:02:53,131 --> 00:02:54,799 - Okay, stop right there. 44 00:02:54,883 --> 00:02:58,594 Let's swap this out to play over Dr. Macchiarini talking 45 00:02:58,678 --> 00:03:00,888 about the initial diagnosis. 46 00:03:00,972 --> 00:03:03,349 [sighs] I think we still need a little more B-roll 47 00:03:03,433 --> 00:03:06,686 with the parents, but we are close to locking. 48 00:03:06,770 --> 00:03:08,187 Ow. 49 00:03:08,271 --> 00:03:09,563 - You okay? - Yeah, I'm okay. 50 00:03:09,647 --> 00:03:12,400 [exhales deeply] [cell phone vibrating] 51 00:03:15,153 --> 00:03:16,487 Hi. 52 00:03:16,571 --> 00:03:18,781 I was just talking about you. 53 00:03:18,865 --> 00:03:21,158 - Uh, Benita. 54 00:03:21,242 --> 00:03:22,827 - Daryl? 55 00:03:22,911 --> 00:03:24,203 - I called to, um-- 56 00:03:24,287 --> 00:03:26,998 I called to tell you she, uh-- 57 00:03:27,082 --> 00:03:28,332 she's gone. 58 00:03:28,416 --> 00:03:30,793 [door closes] - What? 59 00:03:30,877 --> 00:03:33,212 - Hannah's gone. 60 00:03:33,296 --> 00:03:37,383 - What--what do you mean she's gone? 61 00:03:37,467 --> 00:03:39,844 - It was-- There were complications. 62 00:03:39,928 --> 00:03:43,889 Her--her lungs, after all the time in the hospital, 63 00:03:43,973 --> 00:03:48,019 she just-- her body couldn't, um... 64 00:03:48,103 --> 00:03:50,229 Hannah's gone. 65 00:03:50,313 --> 00:03:53,524 We were with her, and she just kept getting worse. 66 00:03:53,608 --> 00:03:56,152 We thought maybe she was gonna-- 67 00:03:56,236 --> 00:03:58,404 that it would pass, but, uh-- 68 00:03:58,488 --> 00:04:01,282 [continues indistinctly, voice fades] 69 00:04:01,366 --> 00:04:04,910 ♪ ♪ 70 00:04:04,994 --> 00:04:09,332 [cell phone vibrating] 71 00:04:09,416 --> 00:04:12,043 - Mom, your phone. 72 00:04:12,127 --> 00:04:15,338 [vibrating continues] 73 00:04:15,422 --> 00:04:19,717 [phone clatters lightly] 74 00:04:19,801 --> 00:04:23,013 Is it work? - No, it's not work. 75 00:04:24,472 --> 00:04:26,599 What's up with the braids, kiddo? 76 00:04:26,683 --> 00:04:29,560 I haven't seen you repeat a hairstyle twice, 77 00:04:29,644 --> 00:04:33,397 let alone three times, in a week. 78 00:04:33,481 --> 00:04:35,817 - Dad liked my hair this way. 79 00:04:41,448 --> 00:04:44,533 - I miss him, too. 80 00:04:44,617 --> 00:04:47,912 But I think you look great. 81 00:04:47,996 --> 00:04:49,288 You ready for school? 82 00:04:49,372 --> 00:04:53,460 [cell phone vibrating] 83 00:05:05,430 --> 00:05:07,056 What are you doing here? 84 00:05:07,140 --> 00:05:08,849 - I wanted to make sure that you're okay. 85 00:05:08,933 --> 00:05:11,143 You're not answering my phone calls, my texts. 86 00:05:11,227 --> 00:05:12,520 - You shouldn't be here. 87 00:05:12,604 --> 00:05:14,773 - I know you heard about Hannah. 88 00:05:17,692 --> 00:05:22,321 I just wanted to make sure that you're okay, Benita. 89 00:05:22,405 --> 00:05:24,907 - I thought she was getting better. 90 00:05:24,991 --> 00:05:27,451 - There were complications. - "Complications. 91 00:05:27,535 --> 00:05:28,869 "Fragile native tissue. 92 00:05:28,953 --> 00:05:30,204 Weakening of the lungs." 93 00:05:30,288 --> 00:05:33,457 I-I read the reports, Paolo. I know the medicine. 94 00:05:33,541 --> 00:05:36,586 But you told me she was getting better. 95 00:05:36,670 --> 00:05:40,172 - She was very sick. 96 00:05:40,256 --> 00:05:42,883 And she was going to die. 97 00:05:42,967 --> 00:05:44,135 I tried. 98 00:05:46,680 --> 00:05:49,307 You think that I'm not upset? 99 00:05:49,391 --> 00:05:51,517 But I won't give up. 100 00:05:51,601 --> 00:05:54,061 I don't have the right to give up. 101 00:05:54,145 --> 00:05:58,524 - No, Paolo, don't. I-I can't do this. 102 00:05:58,608 --> 00:06:02,194 Let's just call it what it is, okay? 103 00:06:02,278 --> 00:06:04,530 - What is it? 104 00:06:04,614 --> 00:06:06,616 - A mistake. 105 00:06:08,868 --> 00:06:10,661 - Colleagues, board members, 106 00:06:10,745 --> 00:06:12,663 we are so glad to have you here 107 00:06:12,747 --> 00:06:14,248 for this momentous occasion. 108 00:06:14,332 --> 00:06:18,502 Tomorrow we will perform the first-ever human transplant 109 00:06:18,586 --> 00:06:20,796 using a bioartificial scaffold. 110 00:06:20,880 --> 00:06:23,507 Our patient is Andemariam Beyene, 111 00:06:23,591 --> 00:06:26,969 a 36-year-old Eritrean PhD student 112 00:06:27,053 --> 00:06:28,679 living in Iceland. 113 00:06:28,763 --> 00:06:31,474 Two years ago, he developed a malignant tumor 114 00:06:31,558 --> 00:06:33,100 in his windpipe. 115 00:06:33,184 --> 00:06:37,021 They have tried radiation and surgical intervention. 116 00:06:37,105 --> 00:06:38,356 All failed. 117 00:06:38,440 --> 00:06:41,525 So his doctors referred him to us. 118 00:06:41,609 --> 00:06:43,194 As you all know, we only have approval 119 00:06:43,278 --> 00:06:46,989 to perform this procedure as compassionate use, 120 00:06:47,073 --> 00:06:48,366 a last resort. 121 00:06:48,450 --> 00:06:50,701 We have designed a biosynthetic trachea 122 00:06:50,785 --> 00:06:53,496 tailor-made to Mr. Beyene's anatomy, 123 00:06:53,580 --> 00:06:55,748 down to the last micrometer. 124 00:06:55,832 --> 00:06:58,000 - And this truly is the breakthrough 125 00:06:58,084 --> 00:07:00,753 that will launch us as a global destination 126 00:07:00,837 --> 00:07:02,505 for this kind of medicine. 127 00:07:02,589 --> 00:07:03,923 - Ladies and gentlemen, 128 00:07:04,007 --> 00:07:08,094 I present to you the future of regenerative medicine. 129 00:07:08,178 --> 00:07:11,639 [dramatic music] 130 00:07:11,723 --> 00:07:13,891 Within weeks, it will grow tissue, 131 00:07:13,975 --> 00:07:17,228 transforming into an actual, living trachea. 132 00:07:17,312 --> 00:07:20,982 ♪ ♪ 133 00:07:21,066 --> 00:07:24,235 - [coughs] 134 00:07:24,319 --> 00:07:27,488 Dr. Macchiarini, I am sorry. 135 00:07:27,572 --> 00:07:30,533 I no longer wish to have the surgery. 136 00:07:30,617 --> 00:07:33,828 We feel it is too risky. 137 00:07:33,912 --> 00:07:38,249 - It is completely natural to have concerns, Mr. Beyene. 138 00:07:38,333 --> 00:07:39,917 - The trachea, it's plastic. 139 00:07:40,001 --> 00:07:42,712 How can you be sure it will work inside my body? 140 00:07:42,796 --> 00:07:45,047 - There you misunderstand. 141 00:07:45,131 --> 00:07:46,549 It is not plastic. 142 00:07:46,633 --> 00:07:48,843 The trachea is medical-grade 143 00:07:48,927 --> 00:07:52,638 polymeric nano-composite material. 144 00:07:52,722 --> 00:07:55,016 - If I may. - Yeah, of course. 145 00:07:55,100 --> 00:07:58,227 - Mr. Beyene, you're studying lava tubes in Iceland. 146 00:07:58,311 --> 00:07:59,854 Is that right? - Yes. 147 00:07:59,938 --> 00:08:01,647 - I believe the recellularization process 148 00:08:01,731 --> 00:08:03,441 is just like that. 149 00:08:03,525 --> 00:08:04,775 When a volcano erupts, 150 00:08:04,859 --> 00:08:07,528 underground lava rivers create tubes. 151 00:08:07,612 --> 00:08:09,739 When the lava drains, the tubes remain, 152 00:08:09,823 --> 00:08:11,449 but now they're rock solid. 153 00:08:11,533 --> 00:08:13,117 They become a part of the Earth. 154 00:08:13,201 --> 00:08:15,995 And that means they last forever. 155 00:08:16,079 --> 00:08:17,455 That's what your stem cells will do 156 00:08:17,539 --> 00:08:19,206 to the synthetic trachea 157 00:08:19,290 --> 00:08:23,169 to make it last forever as a part of you. 158 00:08:23,253 --> 00:08:26,047 - You're asking my husband to be the first 159 00:08:26,131 --> 00:08:28,841 but offer no guarantee the procedure will work. 160 00:08:28,925 --> 00:08:31,844 - No, we cannot offer guarantees 161 00:08:31,928 --> 00:08:34,764 because it would be irresponsible to do so. 162 00:08:34,848 --> 00:08:38,184 Nothing is guaranteed in medicine. 163 00:08:38,268 --> 00:08:39,852 Even just a year ago, 164 00:08:39,936 --> 00:08:43,356 your options would have been much more limited. 165 00:08:43,440 --> 00:08:46,609 You are very lucky to be the first. 166 00:08:46,693 --> 00:08:48,986 Your doctors referred you to us 167 00:08:49,070 --> 00:08:51,989 because the other treatments failed you. 168 00:08:52,073 --> 00:08:55,743 You could have as little as six months to live. 169 00:08:55,827 --> 00:08:59,705 This is your best chance to see your son grow up. 170 00:08:59,789 --> 00:09:06,921 ♪ ♪ 171 00:09:12,969 --> 00:09:14,304 - Okay. 172 00:09:16,389 --> 00:09:17,807 - Okay. 173 00:09:19,434 --> 00:09:22,436 I think it's very difficult to keep an emotional distance, 174 00:09:22,520 --> 00:09:24,314 especially if it is a child. 175 00:09:26,524 --> 00:09:28,192 - Hey. [key clacks] 176 00:09:28,276 --> 00:09:31,195 How you holding up? 177 00:09:31,279 --> 00:09:33,030 - I wish I felt numb. 178 00:09:33,114 --> 00:09:35,449 I just feel... 179 00:09:35,533 --> 00:09:37,660 everything. 180 00:09:39,954 --> 00:09:42,165 - Give yourself a break, B. 181 00:09:43,958 --> 00:09:47,878 You're not on a schedule here. - [sighs] 182 00:09:47,962 --> 00:09:49,922 - It's gonna take what it takes. 183 00:09:50,006 --> 00:09:54,051 - You know, with Hannah Warren and John... 184 00:09:54,135 --> 00:09:57,179 it's just a whole lot of death. 185 00:09:57,263 --> 00:09:59,182 - How's Lizzi? 186 00:10:01,893 --> 00:10:04,020 - She's really quiet. 187 00:10:05,855 --> 00:10:08,357 I think she's pretending to be okay for me, 188 00:10:08,441 --> 00:10:13,112 which makes me feel guilty, which makes me feel worse. 189 00:10:13,196 --> 00:10:16,366 She's just such a daddy's girl. 190 00:10:18,034 --> 00:10:20,286 And that breaks my heart. 191 00:10:20,370 --> 00:10:23,623 - At least you still have a heart to break. 192 00:10:23,707 --> 00:10:26,334 - Yeah, the pain reminds us we're alive. 193 00:10:26,418 --> 00:10:28,711 It's awesome. 194 00:10:28,795 --> 00:10:30,713 - Work is good? - Work is good. 195 00:10:30,797 --> 00:10:32,632 Work is good. 196 00:10:32,716 --> 00:10:35,176 - Hey, how's that piece coming along? 197 00:10:35,260 --> 00:10:37,595 - Hey, it's not. 198 00:10:37,679 --> 00:10:39,805 It's... 199 00:10:39,889 --> 00:10:41,766 a special about the future of medicine. 200 00:10:41,850 --> 00:10:43,601 It's supposed to be hopeful. 201 00:10:43,685 --> 00:10:46,562 And now I don't have a story at all. 202 00:10:46,646 --> 00:10:49,774 - What about him? - What about him? 203 00:10:49,858 --> 00:10:51,651 - Shift the focus to him, you know? 204 00:10:51,735 --> 00:10:53,194 "Dr. Macchiarini, Miracle Man"-- 205 00:10:53,278 --> 00:10:55,571 a look at the pioneer of generational medicine. 206 00:10:55,655 --> 00:10:57,782 - Regenerative. - Exactly. 207 00:10:57,866 --> 00:10:59,408 - But then what about Hannah? 208 00:10:59,492 --> 00:11:03,245 - She'd still be part of the main story. 209 00:11:03,329 --> 00:11:05,957 Medical breakthroughs are always paved with setbacks. 210 00:11:06,041 --> 00:11:07,750 It doesn't mean that Macchiarini's work 211 00:11:07,834 --> 00:11:09,460 isn't worth believing in. 212 00:11:09,544 --> 00:11:11,462 ♪ ♪ 213 00:11:11,546 --> 00:11:12,964 - Hold on to the hopeful. 214 00:11:13,048 --> 00:11:15,758 - If anybody can make it happen, it's you. 215 00:11:15,842 --> 00:11:21,973 ♪ ♪ 216 00:11:23,600 --> 00:11:25,476 [no audio] 217 00:11:25,560 --> 00:11:28,897 [train rumbling] 218 00:11:39,616 --> 00:11:41,909 [indistinct chatter] - When did the pain start? 219 00:11:41,993 --> 00:11:44,453 - Um, off and on for the last few weeks. 220 00:11:44,537 --> 00:11:46,872 I just thought it was stress or something. 221 00:11:46,956 --> 00:11:50,293 - Would you describe the pain as sharp, dull, or burning? 222 00:11:50,377 --> 00:11:52,753 - Sharp, like-- Aah! [winces] 223 00:11:52,837 --> 00:11:54,547 Like someone's stabbing me. Ow. 224 00:11:54,631 --> 00:11:56,966 - Let's get a CBC, liver enzymes, 225 00:11:57,050 --> 00:11:59,719 urine test, and a CT of the abdomen and pelvis, 226 00:11:59,803 --> 00:12:01,971 plus 30 milligrams of Toradol for the pain. 227 00:12:02,055 --> 00:12:05,099 - So it's my appendix? - It's not your appendix. 228 00:12:05,183 --> 00:12:06,892 - What? No, no, no, no, no. 229 00:12:06,976 --> 00:12:08,603 I have a daughter. She's nine years old. 230 00:12:08,687 --> 00:12:10,187 She just lost her father. 231 00:12:10,271 --> 00:12:11,814 I can't have something wrong with me. 232 00:12:11,898 --> 00:12:14,233 - We just need to run some tests to see what's going on. 233 00:12:14,317 --> 00:12:15,568 - Doctor, they're waiting. 234 00:12:15,652 --> 00:12:17,696 - Is there anyone you want to call? 235 00:12:20,907 --> 00:12:22,241 - [sighs] 236 00:12:22,325 --> 00:12:25,244 [indistinct announcement over PA] 237 00:12:25,328 --> 00:12:27,038 - Hi, excuse me. 238 00:12:31,626 --> 00:12:33,544 Hi. - Hi. 239 00:12:33,628 --> 00:12:35,546 Thank you for coming. I'm sorry. 240 00:12:35,630 --> 00:12:37,715 - No, no, I'm glad you called. 241 00:12:37,799 --> 00:12:39,467 Has the pain subsided? - No. 242 00:12:39,551 --> 00:12:41,260 I think it's worse, actually. 243 00:12:41,344 --> 00:12:42,929 - What did the doctor say? - Nothing. 244 00:12:43,013 --> 00:12:46,599 They just ran a bunch of tests, and no one's told me anything. 245 00:12:46,683 --> 00:12:49,060 I've just been sitting here by myself. 246 00:12:51,980 --> 00:12:54,482 - You CT scan shows uterine fibroids. 247 00:12:54,566 --> 00:12:56,609 - What? What is that? Is that cancer? 248 00:12:56,693 --> 00:12:59,487 - Not at all. They're very common. 249 00:12:59,571 --> 00:13:02,949 Is it okay if I take a look? - Yeah. 250 00:13:03,033 --> 00:13:04,867 - Yeah? - Okay. 251 00:13:04,951 --> 00:13:06,577 [sighs] 252 00:13:06,661 --> 00:13:08,788 - This might hurt a little bit. - Okay. All right. 253 00:13:08,872 --> 00:13:11,916 - Okay. [monitor beeping] 254 00:13:14,878 --> 00:13:18,047 - [groans] - Yeah, I can feel two. 255 00:13:18,131 --> 00:13:19,799 They're about the size of grapefruits. 256 00:13:19,883 --> 00:13:20,967 - What? 257 00:13:21,051 --> 00:13:22,927 - It sounds much worse than what it is. 258 00:13:23,011 --> 00:13:25,221 Don't worry. They will have them removed. 259 00:13:25,305 --> 00:13:26,806 - So I have to have surgery? 260 00:13:26,890 --> 00:13:28,933 - Yeah, but it's a very common procedure. 261 00:13:29,017 --> 00:13:31,978 I'm sure your doctor will walk you through everything. 262 00:13:32,062 --> 00:13:34,397 You're gonna be fine. 263 00:13:34,481 --> 00:13:36,816 Trust me. 264 00:13:36,900 --> 00:13:43,823 ♪ ♪ 265 00:13:48,745 --> 00:13:51,038 - He's got you working late already? 266 00:13:51,122 --> 00:13:52,206 - I'm preparing. 267 00:13:52,290 --> 00:13:54,208 It's something doctors do. 268 00:13:54,292 --> 00:13:56,502 You should try it. - Noted. 269 00:13:56,586 --> 00:13:59,130 - I'll sleep when I'm published. 270 00:14:00,840 --> 00:14:02,550 - [sighs] 271 00:14:02,634 --> 00:14:04,844 - Why don't you like him? 272 00:14:04,928 --> 00:14:07,013 - I don't really like anybody. 273 00:14:07,097 --> 00:14:08,764 - That's true. 274 00:14:08,848 --> 00:14:12,518 Still, so few surgeons want to operate on the throat at all, 275 00:14:12,602 --> 00:14:14,812 and he throws in stem-cell regeneration. 276 00:14:14,896 --> 00:14:17,398 Aren't you interested in his work? 277 00:14:17,482 --> 00:14:20,818 - Yes, yes, I find it all very... 278 00:14:20,902 --> 00:14:22,445 interesting. 279 00:14:22,529 --> 00:14:24,447 - You're an ass. 280 00:14:24,531 --> 00:14:26,073 Look at this. 281 00:14:26,157 --> 00:14:29,535 He has to identify the surgical planes bordering the trachea, 282 00:14:29,619 --> 00:14:31,704 avoid tumor dissemination, 283 00:14:31,788 --> 00:14:33,539 all without exposing the larynx, 284 00:14:33,623 --> 00:14:35,541 the thyroid, the esophagus. 285 00:14:35,625 --> 00:14:36,876 Say what you want. 286 00:14:36,960 --> 00:14:39,045 Dr. Macchiarini's got some balls. 287 00:14:39,129 --> 00:14:41,881 - I guess that's what it takes, huh--some nice big balls? 288 00:14:41,965 --> 00:14:44,008 - Sorry, I didn't mean to offend you. 289 00:14:44,092 --> 00:14:46,010 - Yes, I have tiny balls. 290 00:14:46,094 --> 00:14:47,595 [inhales deeply] 291 00:14:47,679 --> 00:14:49,805 You know, a good surgeon knows when not to cut. 292 00:14:49,889 --> 00:14:52,350 - Fuck that. I'm tired of being on the verge of something. 293 00:14:52,434 --> 00:14:56,228 Too afraid to make the cut-- this is groundbreaking work. 294 00:14:56,312 --> 00:14:58,230 I'm getting in. 295 00:14:58,314 --> 00:15:01,233 - Just watch your back. 296 00:15:01,317 --> 00:15:03,194 - I always do. 297 00:15:05,739 --> 00:15:12,871 ♪ ♪ 298 00:15:25,091 --> 00:15:28,427 [device beeping] 299 00:15:28,511 --> 00:15:31,013 [razor whirring] 300 00:15:31,097 --> 00:15:38,021 ♪ ♪ 301 00:15:58,166 --> 00:16:00,459 - Dr. Svensson. 302 00:16:00,543 --> 00:16:03,296 - Dr. Macchiarini? Uh... 303 00:16:03,380 --> 00:16:07,258 [speaking native language] - [speaking native language] 304 00:16:07,342 --> 00:16:10,428 - Oh, the trials seem to be proceeding nicely. 305 00:16:10,512 --> 00:16:11,596 - Uh, yes. 306 00:16:11,680 --> 00:16:14,056 Um, we're on schedule. 307 00:16:14,140 --> 00:16:15,349 - Good. 308 00:16:15,433 --> 00:16:18,394 Any exciting conclusions so far? 309 00:16:18,478 --> 00:16:20,313 - Well, nothing-- you know, nothing 310 00:16:20,397 --> 00:16:21,981 really determinable yet. 311 00:16:22,065 --> 00:16:24,442 Of course, I won't be able to truly discern 312 00:16:24,526 --> 00:16:26,027 any results until-- 313 00:16:26,111 --> 00:16:28,571 - Yeah, until you completed the trials, of course. 314 00:16:28,655 --> 00:16:30,823 As you can imagine, I'm-- - I'm very anxious 315 00:16:30,907 --> 00:16:33,910 to see any results-- positive or otherwise. 316 00:16:35,537 --> 00:16:36,996 - Well, on the test rats 317 00:16:37,080 --> 00:16:38,998 that have received synthetic tracheas, 318 00:16:39,082 --> 00:16:41,000 so far none have responded negatively. 319 00:16:41,084 --> 00:16:42,877 - Well, that-- that is excellent. 320 00:16:42,961 --> 00:16:45,171 - But as you said, we're still gathering data. 321 00:16:45,255 --> 00:16:47,757 Uh... 322 00:16:47,841 --> 00:16:49,216 the purpose of this trial 323 00:16:49,300 --> 00:16:51,677 is to witness objective results, of course. 324 00:16:51,761 --> 00:16:54,722 - Of course, of course. 325 00:16:54,806 --> 00:16:56,807 - May I ask, is there anything in particular 326 00:16:56,891 --> 00:16:59,226 that is concerning you? - Oh, no, not at all. 327 00:16:59,310 --> 00:17:01,687 I have complete faith in your research, Doctor, 328 00:17:01,771 --> 00:17:03,189 as well as my own. 329 00:17:03,273 --> 00:17:04,982 I'll just leave you to your work. 330 00:17:05,066 --> 00:17:06,317 - Okay. 331 00:17:06,401 --> 00:17:07,610 Yeah. 332 00:17:07,694 --> 00:17:13,825 ♪ ♪ 333 00:17:20,540 --> 00:17:23,668 [distant siren wailing] 334 00:17:28,631 --> 00:17:30,007 - Thank you. - Yeah, no problem. 335 00:17:30,091 --> 00:17:32,802 Oh, thank you, thank you, thank you. 336 00:17:32,886 --> 00:17:34,262 Oh, my God, please. 337 00:17:34,346 --> 00:17:36,973 - Wow, I wish I had that effect on you. 338 00:17:37,057 --> 00:17:38,808 - 48 hours without caffeine? 339 00:17:38,892 --> 00:17:40,352 Who am I today? 340 00:17:43,021 --> 00:17:45,022 - I spelled your name for them. 341 00:17:45,106 --> 00:17:48,109 [distant siren wailing] 342 00:17:48,193 --> 00:17:50,695 You're feeling better? - Mm-hmm. 343 00:17:50,779 --> 00:17:53,906 I am. Like two grapefruits lighter. 344 00:17:53,990 --> 00:17:55,700 Thank you, really. 345 00:17:55,784 --> 00:17:57,077 - Pleasure. 346 00:18:00,121 --> 00:18:02,707 - Paolo... 347 00:18:02,791 --> 00:18:06,210 we've both been through a lot of loss the past few months. 348 00:18:06,294 --> 00:18:09,505 And I know I wasn't dying in there, but I-- 349 00:18:09,589 --> 00:18:11,882 I was really scared, and it... 350 00:18:11,966 --> 00:18:14,051 [dramatic music] 351 00:18:14,135 --> 00:18:15,886 It just-- 352 00:18:15,970 --> 00:18:18,180 it put things in perspective for me. 353 00:18:18,264 --> 00:18:22,143 Us together, it could cost me my job, my reputation, 354 00:18:22,227 --> 00:18:25,896 but I think this thing we have, it's worth the risk. 355 00:18:25,980 --> 00:18:27,815 [distant siren wailing] 356 00:18:27,899 --> 00:18:29,609 - For me, too. 357 00:18:29,693 --> 00:18:34,071 ♪ ♪ 358 00:18:34,155 --> 00:18:36,616 - You've heard the criticism-- 359 00:18:36,700 --> 00:18:39,660 that you're really taking a chance with these patients. 360 00:18:39,744 --> 00:18:41,704 What do you say to that? 361 00:18:41,788 --> 00:18:44,874 - I was raised to believe that if you... 362 00:18:44,958 --> 00:18:48,002 if have even one chance, you need to take it, 363 00:18:48,086 --> 00:18:50,296 because either that patient will die, 364 00:18:50,380 --> 00:18:53,341 or we try to do something, even if it's new. 365 00:18:53,425 --> 00:18:57,303 As a doctor and-- and as a human being, I... 366 00:18:57,387 --> 00:19:01,641 I ask myself, are we allowed to say no? 367 00:19:01,725 --> 00:19:03,267 I don't think we are. 368 00:19:03,351 --> 00:19:05,853 - And when you got that call later 369 00:19:05,937 --> 00:19:08,314 that--that she had passed... - Mm. 370 00:19:08,398 --> 00:19:11,484 - It had to be devastating for you. 371 00:19:11,568 --> 00:19:14,028 - I couldn't stop thinking... 372 00:19:14,112 --> 00:19:17,198 did I make the right decision? 373 00:19:17,282 --> 00:19:19,533 Did I do everything to save her? 374 00:19:19,617 --> 00:19:22,870 There are so many patients all around the world 375 00:19:22,954 --> 00:19:24,413 who need this procedure. 376 00:19:24,497 --> 00:19:27,333 We should really try to achieve this 377 00:19:27,417 --> 00:19:29,043 for all of them, 378 00:19:29,127 --> 00:19:31,128 because even in the face of failure, 379 00:19:31,212 --> 00:19:33,339 we should keep hope alive. 380 00:19:33,423 --> 00:19:37,677 ♪ ♪ 381 00:19:37,761 --> 00:19:39,428 - Great job today, guys. 382 00:19:39,512 --> 00:19:42,223 Dr. Macchiarini, do you mind staying behind 383 00:19:42,307 --> 00:19:44,350 for a few minutes to go over the schedule? 384 00:19:44,434 --> 00:19:45,685 - Good night. 385 00:19:45,769 --> 00:19:48,646 ♪ ♪ 386 00:19:48,730 --> 00:19:50,357 - Of course. 387 00:19:53,276 --> 00:19:54,568 So? 388 00:19:54,652 --> 00:19:56,153 - So... 389 00:19:56,237 --> 00:19:59,448 Well, I have some follow-up questions for you 390 00:19:59,532 --> 00:20:00,533 that are gonna happen... 391 00:20:00,617 --> 00:20:03,828 - Really? - Behind closed doors, yeah. 392 00:20:09,042 --> 00:20:11,878 - I'm so sorry you had to go through this. 393 00:20:13,630 --> 00:20:15,464 - It's okay. 394 00:20:15,548 --> 00:20:18,175 It's just gonna be a scar. 395 00:20:18,259 --> 00:20:19,677 - One day we will live in a world 396 00:20:19,761 --> 00:20:22,597 where we won't have to cut people open to fix them. 397 00:20:22,681 --> 00:20:24,224 You'll see. 398 00:20:26,935 --> 00:20:30,313 - Do you ever have any doubts? 399 00:20:30,397 --> 00:20:31,606 - Of course I do. 400 00:20:31,690 --> 00:20:34,025 - Really? - Mm-hmm. 401 00:20:34,109 --> 00:20:37,237 - 'Cause you seem so sure of all of it. 402 00:20:39,030 --> 00:20:41,449 Even the things that could go wrong, 403 00:20:41,533 --> 00:20:44,160 that have gone wrong... 404 00:20:44,244 --> 00:20:47,330 you just keep moving forward. 405 00:20:47,414 --> 00:20:50,417 - I think a lot about the ones who came before me. 406 00:20:52,669 --> 00:20:55,004 Like Thomas Starzl-- 407 00:20:55,088 --> 00:20:57,882 he started the first liver transplants. 408 00:20:57,966 --> 00:21:00,676 His first patients died. - Hmm. 409 00:21:00,760 --> 00:21:03,304 - Or Christiaan Barnard... 410 00:21:03,388 --> 00:21:06,557 he performed the first heart transplant. 411 00:21:06,641 --> 00:21:08,893 People threw rocks at him. 412 00:21:08,977 --> 00:21:12,480 Everybody thought he was crazy. - [scoffs] 413 00:21:12,564 --> 00:21:14,482 - I'm sure people looked at him the same way 414 00:21:14,566 --> 00:21:16,442 that you're looking at me right now. 415 00:21:16,526 --> 00:21:18,444 [chuckles] 416 00:21:18,528 --> 00:21:21,238 ♪ ♪ 417 00:21:21,322 --> 00:21:24,784 When Hannah died, I did lose faith. 418 00:21:24,868 --> 00:21:27,078 But these doctors, they-- 419 00:21:27,162 --> 00:21:30,706 they believed, they worked, they persevered 420 00:21:30,790 --> 00:21:32,833 until they found their way. 421 00:21:32,917 --> 00:21:34,877 Being the one to try something new, 422 00:21:34,961 --> 00:21:36,337 no matter the personal cost, 423 00:21:36,421 --> 00:21:38,756 is vital to move medicine forward. 424 00:21:38,840 --> 00:21:41,300 It's vital. 425 00:21:41,384 --> 00:21:43,761 And I believe that the work that we're doing 426 00:21:43,845 --> 00:21:47,139 is going to save many lives. 427 00:21:47,223 --> 00:21:49,475 - I believe it will, too. 428 00:21:49,559 --> 00:21:56,191 ♪ ♪ 429 00:22:03,406 --> 00:22:06,575 - Hi, my love. I'm here, missing you in Barcelona. 430 00:22:06,659 --> 00:22:08,619 The lemon trees are ready for you. 431 00:22:08,703 --> 00:22:12,206 - Oh, there is a sushi roll with my name on it. 432 00:22:12,290 --> 00:22:14,875 Benita? - Hmm? Oh, yeah, lunch. 433 00:22:14,959 --> 00:22:16,669 - You ready? - Sorry. Yeah. 434 00:22:16,753 --> 00:22:17,878 - Good. 435 00:22:17,962 --> 00:22:20,840 [dramatic classical music] 436 00:22:20,924 --> 00:22:25,970 ♪ ♪ 437 00:22:26,054 --> 00:22:27,972 [Benita laugh] 438 00:22:28,056 --> 00:22:30,057 ♪ ♪ 439 00:22:30,141 --> 00:22:32,143 - Mm. - Come on, come on... 440 00:22:32,227 --> 00:22:39,359 ♪ ♪ 441 00:22:40,485 --> 00:22:42,528 No, I hear you. The information is great. 442 00:22:42,612 --> 00:22:44,280 But I'm going to need another source on it 443 00:22:44,364 --> 00:22:47,033 to confirm her account. 444 00:22:47,117 --> 00:22:49,076 Sure. Could you email that to me? 445 00:22:49,160 --> 00:22:51,370 Wow, that sounds good. 446 00:22:51,454 --> 00:22:52,955 Yeah. 447 00:22:53,039 --> 00:22:55,041 [whispering] It's Lizzi. Okay. - [whispering] I'll miss you. 448 00:22:55,125 --> 00:22:57,209 - Yeah. Sure. 449 00:22:57,293 --> 00:22:58,711 It's okay with me. 450 00:22:58,795 --> 00:23:01,797 If it's okay with Aubrey's mom, you can sleep over. 451 00:23:01,881 --> 00:23:05,426 Okay. I love you, too. Bye. 452 00:23:05,510 --> 00:23:07,595 - Did you say "sleep over"? - Yeah. 453 00:23:07,679 --> 00:23:10,056 - Maybe I could change my flight. 454 00:23:10,140 --> 00:23:12,350 - Oh, I didn't know that was an option. 455 00:23:12,434 --> 00:23:13,768 - Mm-hmm. 456 00:23:13,852 --> 00:23:20,816 ♪ ♪ 457 00:23:20,900 --> 00:23:22,944 - What? - The Stones are sexier. 458 00:23:23,028 --> 00:23:24,445 - No, no, no. - That's it. 459 00:23:24,529 --> 00:23:27,406 - How can you even compare them? 460 00:23:27,490 --> 00:23:29,784 - I've always thought this, and I'm not going to apologize. 461 00:23:29,868 --> 00:23:31,160 - "Blackbird," um... 462 00:23:31,244 --> 00:23:32,620 - [laughs] - "Martha My Dear," 463 00:23:32,704 --> 00:23:34,956 "While My Guitar Gently Weeps," "Rocky Raccoon." 464 00:23:35,040 --> 00:23:36,290 - Okay, now we're listing songs? 465 00:23:36,374 --> 00:23:38,000 - Yeah. - "Satisfaction"... 466 00:23:38,084 --> 00:23:39,919 - Oh. - "Gimme Shelter," 467 00:23:40,003 --> 00:23:41,629 "Sympathy for the Devil." - No. 468 00:23:41,713 --> 00:23:43,464 No, we can't have this conversation. 469 00:23:43,548 --> 00:23:45,675 This is terrible. Now I have to leave you. 470 00:23:45,759 --> 00:23:47,301 - Are you gonna leave me? - I'm gonna leave you. 471 00:23:47,385 --> 00:23:48,719 - Are you gonna leave me for The Beatles? 472 00:23:48,803 --> 00:23:50,388 - This is a very, very... - They're almost-- 473 00:23:50,472 --> 00:23:52,431 All of them are dead, almost. - Important distinction. 474 00:23:52,515 --> 00:23:54,850 [both laugh] 475 00:23:54,934 --> 00:23:57,437 [doorbell ringing] 476 00:23:59,356 --> 00:24:02,024 - Italian "Vogue," nice touch. 477 00:24:02,108 --> 00:24:04,277 - For Lizzi. - Ah. 478 00:24:06,404 --> 00:24:10,324 Hey, Lizzi? My friend Paolo is here. 479 00:24:10,408 --> 00:24:13,828 - Your "friend"? - My friend. 480 00:24:13,912 --> 00:24:16,789 [soft music playing] 481 00:24:16,873 --> 00:24:23,296 ♪ ♪ 482 00:24:23,380 --> 00:24:26,173 - "Cacio" means "cheese," 483 00:24:26,257 --> 00:24:30,094 and "pepe" means "pepper." 484 00:24:30,178 --> 00:24:32,346 So it's like Italian mac and cheese. 485 00:24:32,430 --> 00:24:34,015 [phone vibrating, Benita chuckles] 486 00:24:34,099 --> 00:24:36,726 And pepper, you know, "pepe." 487 00:24:36,810 --> 00:24:38,644 - It's delicious, right? 488 00:24:38,728 --> 00:24:41,314 What do you think, kiddo? 489 00:24:41,398 --> 00:24:43,441 - I don't like it. 490 00:24:43,525 --> 00:24:48,237 ♪ ♪ 491 00:24:48,321 --> 00:24:50,531 - Your mom tells me that you play the violin. 492 00:24:50,615 --> 00:24:52,074 - She does, yeah. - Yeah? 493 00:24:52,158 --> 00:24:53,534 - She practices every day. 494 00:24:53,618 --> 00:24:55,494 Sometimes I don't even have to ask her to practice. 495 00:24:55,578 --> 00:24:57,663 - Oh, wow. That's impressive. 496 00:24:57,747 --> 00:24:59,081 It's impressive, 497 00:24:59,165 --> 00:25:02,209 'cause I used to play the piano when I was your age, 498 00:25:02,293 --> 00:25:04,337 but I hated to practice. [Benita chuckles] 499 00:25:04,421 --> 00:25:05,880 Well, maybe we can play together. 500 00:25:05,964 --> 00:25:08,215 You--you play the violin, and I play the piano. 501 00:25:08,299 --> 00:25:10,551 We make a concert for your mom. 502 00:25:10,635 --> 00:25:13,429 ♪ ♪ 503 00:25:13,513 --> 00:25:14,847 Mm. 504 00:25:14,931 --> 00:25:17,725 Did you hear what happened when Johann Sebastian Bach 505 00:25:17,809 --> 00:25:19,769 dropped his violin? 506 00:25:19,853 --> 00:25:21,896 It Baroque. 507 00:25:21,980 --> 00:25:23,814 It Ba-roque. 508 00:25:23,898 --> 00:25:25,733 - Ba-roque, that's funny. 509 00:25:25,817 --> 00:25:29,236 - Can I go to my room? - Lizzi, come on, please. 510 00:25:29,320 --> 00:25:31,948 - No, it's okay. [Benita stammers] 511 00:25:32,032 --> 00:25:34,575 But, Lizzi... 512 00:25:34,659 --> 00:25:38,663 I know that you're feeling a thousand things right now, 513 00:25:38,747 --> 00:25:39,997 all at once. 514 00:25:40,081 --> 00:25:42,959 And I'm ready to wait for as long as it takes 515 00:25:43,043 --> 00:25:46,045 for you to figure out how you feel about me. 516 00:25:46,129 --> 00:25:47,713 But I'll make you a deal. 517 00:25:47,797 --> 00:25:49,590 If you let me show you 518 00:25:49,674 --> 00:25:52,802 how much I care about your mom, 519 00:25:52,886 --> 00:25:55,763 I promise you I will never make you eat 520 00:25:55,847 --> 00:25:58,599 my cacio e pepe again. 521 00:25:58,683 --> 00:26:00,518 Accordo? 522 00:26:00,602 --> 00:26:03,938 ♪ ♪ 523 00:26:04,022 --> 00:26:05,147 - Accordo. 524 00:26:05,231 --> 00:26:07,358 ♪ ♪ 525 00:26:07,442 --> 00:26:10,611 - Good night. 526 00:26:10,695 --> 00:26:13,447 [clears throat] [door closes] 527 00:26:13,531 --> 00:26:16,367 [chuckles] - She'll get there. 528 00:26:16,451 --> 00:26:17,952 It takes time. 529 00:26:18,036 --> 00:26:20,329 ♪ ♪ 530 00:26:20,413 --> 00:26:21,622 It's really good. 531 00:26:21,706 --> 00:26:22,915 - But you got it, right, Baroque? 532 00:26:22,999 --> 00:26:23,958 - I got Baroque. - Okay. 533 00:26:24,042 --> 00:26:25,960 - Yeah, it's a cute joke. 534 00:26:26,044 --> 00:26:32,800 ♪ ♪ 535 00:26:32,884 --> 00:26:36,929 Hey, three more pages, then jammies and lights out, okay? 536 00:26:37,013 --> 00:26:38,598 - Okay. 537 00:26:38,682 --> 00:26:41,475 ♪ ♪ 538 00:26:41,559 --> 00:26:44,020 - I love you. - I love you, too. 539 00:26:44,104 --> 00:26:45,813 - Good night. 540 00:26:45,897 --> 00:26:47,231 - Hey, Mom? 541 00:26:47,315 --> 00:26:49,275 ♪ ♪ 542 00:26:49,359 --> 00:26:51,652 I like his accent. 543 00:26:51,736 --> 00:26:55,907 ♪ ♪ 544 00:26:57,367 --> 00:27:00,453 [Paolo speaking Russian] 545 00:27:05,041 --> 00:27:07,126 - What? Are you kidding me? You cooked. 546 00:27:07,210 --> 00:27:08,336 Get out of here. 547 00:27:08,420 --> 00:27:11,464 - [speaking Russian] 548 00:27:16,052 --> 00:27:17,929 - What? 549 00:27:18,013 --> 00:27:20,181 - I have bad news. 550 00:27:20,265 --> 00:27:22,475 Our trip to Barcelona-- - No! 551 00:27:22,559 --> 00:27:24,894 - I have to cancel. - Oh. 552 00:27:24,978 --> 00:27:27,021 - Uh, there's-- there's a new patient 553 00:27:27,105 --> 00:27:28,898 I need to meet in Moscow. 554 00:27:28,982 --> 00:27:31,525 - I was so looking forward to finally seeing your place. 555 00:27:31,609 --> 00:27:33,361 - I know, my love, and I'm so sorry, 556 00:27:33,445 --> 00:27:34,737 but if she agrees to surgery, 557 00:27:34,821 --> 00:27:36,989 this could launch funding for the entire lab. 558 00:27:37,073 --> 00:27:38,449 - No, I-I get it, I get it. 559 00:27:38,533 --> 00:27:41,619 I just, um... 560 00:27:41,703 --> 00:27:44,372 have to figure out what to tell Kim and everybody else, 561 00:27:44,456 --> 00:27:46,040 'cause I already took time off. 562 00:27:46,124 --> 00:27:48,209 And I have Laura coming to stay with Lizzi and-- 563 00:27:48,293 --> 00:27:50,336 - Why don't you come with me? 564 00:27:50,420 --> 00:27:52,546 - To Russia? - To Moscow. 565 00:27:52,630 --> 00:27:54,883 I can show you off in Moscow. 566 00:27:56,468 --> 00:27:57,885 - I don't know. [chuckles] 567 00:27:57,969 --> 00:28:00,054 - Oh, come on, Benita, I want to spend time with you 568 00:28:00,138 --> 00:28:01,931 without having to hide--please. 569 00:28:02,015 --> 00:28:04,767 - We have to wait until the special airs 570 00:28:04,851 --> 00:28:06,560 before we tell anybody anything. 571 00:28:06,644 --> 00:28:09,105 - I'm sure our secret will be safe in Russia. 572 00:28:09,189 --> 00:28:10,815 Please come with me. 573 00:28:10,899 --> 00:28:13,317 Please, come with me. - Okay. 574 00:28:13,401 --> 00:28:14,986 I mean, who-- 575 00:28:15,070 --> 00:28:19,031 who am I to say no to the great Dr. Macchiarini. 576 00:28:19,115 --> 00:28:23,703 ♪ ♪ 577 00:28:23,787 --> 00:28:26,330 [device beeping] 578 00:28:26,414 --> 00:28:30,126 [monitor beeping] 579 00:28:30,210 --> 00:28:32,378 - Accessing the cricoid ring. 580 00:28:32,462 --> 00:28:35,381 [dramatic music] 581 00:28:35,465 --> 00:28:39,594 ♪ ♪ 582 00:28:39,678 --> 00:28:42,513 I see severe infection, most likely caused 583 00:28:42,597 --> 00:28:45,391 by the excessive radiation treatments on the patient. 584 00:28:45,475 --> 00:28:47,435 The cartilage is necrotic. 585 00:28:47,519 --> 00:28:49,312 If the tumor hadn't killed him, 586 00:28:49,396 --> 00:28:50,938 it would have been only a matter of time 587 00:28:51,022 --> 00:28:53,107 before he succumbed to infection. 588 00:28:53,191 --> 00:28:57,695 ♪ ♪ 589 00:28:57,779 --> 00:28:59,113 Knife. 590 00:28:59,197 --> 00:29:02,491 ♪ ♪ 591 00:29:02,575 --> 00:29:04,493 Starting resection. 592 00:29:04,577 --> 00:29:08,581 The biosynthetic trachea will fit perfectly 593 00:29:08,665 --> 00:29:10,124 in the resected area. 594 00:29:10,208 --> 00:29:17,132 ♪ ♪ 595 00:29:30,520 --> 00:29:32,146 [device beeping] 596 00:29:32,230 --> 00:29:35,149 [monitor beeping] 597 00:29:35,233 --> 00:29:37,485 ♪ ♪ 598 00:29:37,569 --> 00:29:38,945 Metzenbaum. 599 00:29:39,029 --> 00:29:45,952 ♪ ♪ 600 00:29:48,371 --> 00:29:50,164 [scissors snipping] 601 00:29:50,248 --> 00:29:56,420 ♪ ♪ 602 00:29:56,504 --> 00:29:58,214 Okay. 603 00:29:58,298 --> 00:30:05,430 ♪ ♪ 604 00:30:21,613 --> 00:30:25,199 Okay, switch the oxygen input. 605 00:30:25,283 --> 00:30:30,162 ♪ ♪ 606 00:30:30,246 --> 00:30:31,956 Saline. 607 00:30:32,040 --> 00:30:35,459 Any leaks in the trachea will produce bubbles in the saline. 608 00:30:35,543 --> 00:30:38,504 ♪ ♪ 609 00:30:38,588 --> 00:30:40,339 Pulse ox? 610 00:30:40,423 --> 00:30:42,216 - Holding steady. 611 00:30:42,300 --> 00:30:45,052 ♪ ♪ 612 00:30:45,136 --> 00:30:47,054 - No signs of leaking. 613 00:30:47,138 --> 00:30:50,850 - Oxygen holding, 98%. 614 00:30:52,185 --> 00:30:53,561 - It's working. 615 00:30:53,645 --> 00:30:56,230 - Congratulations, Doctor. 616 00:30:56,314 --> 00:30:58,774 - Okay, let's close him up. 617 00:30:58,858 --> 00:31:01,068 [alarm blaring] - Doctor? 618 00:31:01,152 --> 00:31:02,445 - BP's dropping. 619 00:31:02,529 --> 00:31:04,488 - He's bleeding. - Vitals are weakening. 620 00:31:04,572 --> 00:31:06,407 - No, it can't be. The implant is working. 621 00:31:06,491 --> 00:31:08,701 Where is this blood coming from? 622 00:31:08,785 --> 00:31:10,911 [blaring continues] - Doctor? 623 00:31:10,995 --> 00:31:12,830 The left carotid's most likely ruptured. 624 00:31:12,914 --> 00:31:14,582 - No, I didn't touch it. I wasn't even near it. 625 00:31:14,666 --> 00:31:16,042 - You said there was radiation damage. 626 00:31:16,126 --> 00:31:17,251 - Losing OX. 627 00:31:17,335 --> 00:31:18,920 - It must have weakened the vascular wall. 628 00:31:19,004 --> 00:31:20,588 - Doctor. - Blood pressure is dropping. 629 00:31:20,672 --> 00:31:22,256 - Doctor, we need to do something. 630 00:31:22,340 --> 00:31:23,466 - Doctor? - Losing oxygen. 631 00:31:23,550 --> 00:31:25,009 - Doctor? 632 00:31:25,093 --> 00:31:26,510 Paolo! 633 00:31:26,594 --> 00:31:29,597 I can fix this. 634 00:31:29,681 --> 00:31:31,766 - He needs to be stabilized. 635 00:31:31,850 --> 00:31:34,143 [beeping and blaring continue] 636 00:31:34,227 --> 00:31:37,313 - Suction? - Blood pressure is dropping. 637 00:31:37,397 --> 00:31:42,735 ♪ ♪ 638 00:31:42,819 --> 00:31:44,695 - Found it. Cautery. 639 00:31:44,779 --> 00:31:48,199 [beeping and blaring continue] 640 00:31:48,283 --> 00:31:55,206 ♪ ♪ 641 00:31:58,793 --> 00:32:02,088 [monitor beeping] - BP is on the rise. 642 00:32:02,172 --> 00:32:03,923 - He's stable. 643 00:32:04,007 --> 00:32:07,176 Sutures for Dr. Macchiarini. 644 00:32:07,260 --> 00:32:09,596 - You should close him. 645 00:32:13,808 --> 00:32:15,768 [door closes] 646 00:32:15,852 --> 00:32:17,937 [indistinct chatter] 647 00:32:22,484 --> 00:32:25,361 [dramatic classical music] 648 00:32:25,445 --> 00:32:32,577 ♪ ♪ 649 00:32:42,796 --> 00:32:45,464 - [speaking Russian] - [speaking Russian] 650 00:32:45,548 --> 00:32:47,383 - [speaking Russian] - [speaking Russian] 651 00:32:47,467 --> 00:32:50,219 All right, my love, this way. 652 00:32:50,303 --> 00:32:51,721 - I was texting with Lizzi 653 00:32:51,805 --> 00:32:53,639 about setting up our Skype call. 654 00:32:53,723 --> 00:32:54,974 - Mm-hmm? 655 00:32:55,058 --> 00:32:57,059 - And she specifically asked for you to jump on. 656 00:32:57,143 --> 00:32:58,644 - Oh, she did? - Yeah. 657 00:32:58,728 --> 00:33:00,855 You charmed her, you big charmer. 658 00:33:00,939 --> 00:33:02,898 - [laughs] 659 00:33:02,982 --> 00:33:04,859 - [speaking Russian] 660 00:33:09,406 --> 00:33:11,657 - Pardon me. 661 00:33:11,741 --> 00:33:14,076 Uh, compliments of the gentleman at the bar. 662 00:33:14,160 --> 00:33:19,874 ♪ ♪ 663 00:33:19,958 --> 00:33:21,334 - Thank you. 664 00:33:21,418 --> 00:33:23,377 [chuckles] 665 00:33:23,461 --> 00:33:27,715 - To you, to me, and to ice buckets, always. 666 00:33:27,799 --> 00:33:29,676 - [chuckles] Cheers. 667 00:33:33,013 --> 00:33:35,681 So who is our benefactor this evening? 668 00:33:35,765 --> 00:33:38,100 - I shouldn't say. - Paolo, come on. 669 00:33:38,184 --> 00:33:40,520 I protect sources for a living. 670 00:33:42,647 --> 00:33:45,942 - He's a Russian oligarch, very connected. 671 00:33:46,026 --> 00:33:48,319 No, don't look. 672 00:33:48,403 --> 00:33:50,780 There is a network of high-profile patients, 673 00:33:50,864 --> 00:33:53,741 celebrities, clergy, presidents 674 00:33:53,825 --> 00:33:57,203 that are treated in secret, that I treat in secret. 675 00:33:57,287 --> 00:33:58,621 Because of who they are, 676 00:33:58,705 --> 00:34:01,749 I have to keep our arrangement quiet. 677 00:34:01,833 --> 00:34:06,003 - Presidents, like U.S. presidents? 678 00:34:06,087 --> 00:34:07,713 - [clears throat] 679 00:34:07,797 --> 00:34:11,676 - Paolo Macchiarini, surgeon to the stars? 680 00:34:11,760 --> 00:34:14,303 - [chuckles] - Okay. 681 00:34:14,387 --> 00:34:16,555 I--Somebody's got to do it, right? 682 00:34:16,639 --> 00:34:18,725 - Shh, they're coming. - Oh. [clears throat] 683 00:34:21,436 --> 00:34:24,522 - Yulia, this is Benita Alexander. 684 00:34:24,606 --> 00:34:27,942 - Paolo, good to see you. - It's nice to meet you. 685 00:34:28,026 --> 00:34:29,318 [Benita chuckles] 686 00:34:29,402 --> 00:34:32,196 [chuckles] If you're trying to impress me, Doctor, 687 00:34:32,280 --> 00:34:33,531 it's--it's working. 688 00:34:33,615 --> 00:34:35,908 - Yulia, my dear, for you, only the best. 689 00:34:35,992 --> 00:34:38,995 - Uh, Paolo tells me you're a dancer. 690 00:34:39,079 --> 00:34:41,330 - The best in Russia. - [scoffs] 691 00:34:41,414 --> 00:34:44,792 - I met Andrej not long after I joined the Bolshoi. 692 00:34:44,876 --> 00:34:46,377 - I saw her perform in "Swan Lake." 693 00:34:46,461 --> 00:34:48,170 She was magnificent. 694 00:34:48,254 --> 00:34:50,840 - I was only part of the corps de ballet, not the soloist. 695 00:34:50,924 --> 00:34:53,175 - Still, I could not take my eyes off of her. 696 00:34:53,259 --> 00:34:54,594 [both laugh] 697 00:34:54,678 --> 00:34:57,471 - While I was on tour in London a few years ago, 698 00:34:57,555 --> 00:35:01,559 I was involved in a horrible car accident. 699 00:35:01,643 --> 00:35:03,519 - It's a miracle she's even alive. 700 00:35:03,603 --> 00:35:05,646 - My windpipe was broken. My... 701 00:35:05,730 --> 00:35:07,481 Everything was broken. 702 00:35:07,565 --> 00:35:10,443 And it left me with this hole in my neck. 703 00:35:10,527 --> 00:35:11,986 - I'm so sorry. 704 00:35:12,070 --> 00:35:15,698 - The past is a lighthouse, not a port. 705 00:35:15,782 --> 00:35:19,243 [chuckles] I found Dr. Macchiarini. 706 00:35:19,327 --> 00:35:22,538 - Up until now, we have implanted 707 00:35:22,622 --> 00:35:24,498 only patients for compassionate use, 708 00:35:24,582 --> 00:35:27,209 those who otherwise would die. 709 00:35:27,293 --> 00:35:30,713 But you have shown me that quality of life 710 00:35:30,797 --> 00:35:33,883 is nearly as important as life itself. 711 00:35:33,967 --> 00:35:36,719 - So this is an elective surgery? 712 00:35:36,803 --> 00:35:38,846 - Yeah. - Mm. 713 00:35:38,930 --> 00:35:41,140 A part of me 714 00:35:41,224 --> 00:35:45,895 hopes it will allow me to dance again, but, mostly... 715 00:35:45,979 --> 00:35:49,565 we have a two-year-old son, Sasha. 716 00:35:49,649 --> 00:35:52,234 I want to play with him... [chuckles] 717 00:35:52,318 --> 00:35:54,070 Sing him a lullaby. 718 00:35:54,154 --> 00:35:56,113 - And you're the perfect candidate. 719 00:35:56,197 --> 00:35:58,282 You're young, healthy, 720 00:35:58,366 --> 00:36:01,077 no other medical issues that would complicate matters. 721 00:36:01,161 --> 00:36:03,245 You-- you're ready. 722 00:36:03,329 --> 00:36:05,247 - Mm. I really don't want to go to Sweden. 723 00:36:05,331 --> 00:36:09,919 I wish you were set up to operate in Russia. 724 00:36:10,003 --> 00:36:13,089 - Then I have great news for you. 725 00:36:13,173 --> 00:36:15,716 Our colleague, Dr. Lasbrey, is setting up facilities 726 00:36:15,800 --> 00:36:18,386 in Krasnodar as we speak. 727 00:36:18,470 --> 00:36:21,764 Your procedure will launch our work here in Russia, Yulia. 728 00:36:21,848 --> 00:36:24,934 You will have your operation here. 729 00:36:25,018 --> 00:36:26,936 - [chuckles] 730 00:36:27,020 --> 00:36:28,938 - [chuckles] 731 00:36:29,022 --> 00:36:31,274 - To Dr. Paolo Macchiarini... - Ah. 732 00:36:31,358 --> 00:36:33,567 - Our rock-star surgeon. 733 00:36:33,651 --> 00:36:36,070 [all speaking Russian] 734 00:36:36,154 --> 00:36:38,864 [dramatic music] 735 00:36:38,948 --> 00:36:41,325 - Mm. 736 00:36:41,409 --> 00:36:42,952 - You okay? - Mm-hmm. 737 00:36:43,036 --> 00:36:44,704 - Yeah? - Yeah, I'm okay. 738 00:36:44,788 --> 00:36:47,373 ♪ ♪ 739 00:36:47,457 --> 00:36:50,126 [signal chiming] 740 00:36:50,210 --> 00:36:53,045 - This ballet was first performed in 1871. 741 00:36:53,129 --> 00:36:54,714 You know-- 742 00:36:54,798 --> 00:36:57,174 Are you okay? 743 00:36:57,258 --> 00:36:59,468 - [groans] - Hey. Hey, hey, hey, my love. 744 00:36:59,552 --> 00:37:02,680 - [wincing] - Hey, are you okay? 745 00:37:02,764 --> 00:37:04,724 - I'm sorry. I don't think I can-- 746 00:37:04,808 --> 00:37:06,809 - No, no, no, we'll go home. No, we'll go. I text you. 747 00:37:06,893 --> 00:37:08,644 No, she's-- I'll text you, okay? 748 00:37:08,728 --> 00:37:10,479 Let's go. - Are you sure? Should I-- 749 00:37:10,563 --> 00:37:11,731 - Yes. Yeah, yeah. 750 00:37:11,815 --> 00:37:14,609 ♪ ♪ 751 00:37:14,693 --> 00:37:16,027 - You're getting worse. 752 00:37:16,111 --> 00:37:17,987 You should have let me take you to the hospital. 753 00:37:18,071 --> 00:37:20,239 - No, I just want to lie down. 754 00:37:20,323 --> 00:37:23,701 [groaning] 755 00:37:23,785 --> 00:37:27,330 - You're burning up. - Mm. I feel sick. 756 00:37:27,414 --> 00:37:29,082 - Let me check something. 757 00:37:31,751 --> 00:37:33,794 The surgical site is infected. 758 00:37:33,878 --> 00:37:35,880 - What? There's no way. That was months ago. 759 00:37:35,964 --> 00:37:38,716 It's got to be healed by now. - No, it's not. 760 00:37:38,800 --> 00:37:41,469 - [groaning] 761 00:37:41,553 --> 00:37:46,682 ♪ ♪ 762 00:37:46,766 --> 00:37:49,727 - So--so what, antibiotics or something? 763 00:37:49,811 --> 00:37:52,355 - No, it's too late for that. 764 00:37:52,439 --> 00:37:56,150 You're in sepsis. I need to debride your wound. 765 00:37:56,234 --> 00:37:57,944 Otherwise, you will go into shock. 766 00:37:58,028 --> 00:38:00,863 - "Debride"? What does that mean? 767 00:38:00,947 --> 00:38:03,199 - You're gonna be okay. - [groans] 768 00:38:03,283 --> 00:38:06,619 [breathing heavily] 769 00:38:06,703 --> 00:38:08,371 Do you trust me? 770 00:38:08,455 --> 00:38:11,624 ♪ ♪ 771 00:38:11,708 --> 00:38:13,376 - Mm-hmm. 772 00:38:13,460 --> 00:38:17,213 ♪ ♪ 773 00:38:17,297 --> 00:38:21,467 [breathing heavily] 774 00:38:21,551 --> 00:38:24,387 [groaning] 775 00:38:24,471 --> 00:38:27,932 ♪ ♪ 776 00:38:28,016 --> 00:38:31,644 [groans loudly, breathing heavily] 777 00:38:31,728 --> 00:38:34,773 [grunts, screams] 778 00:38:41,363 --> 00:38:42,363 [applause] 779 00:38:42,447 --> 00:38:43,990 - "Two months after transplantation, 780 00:38:44,074 --> 00:38:45,700 "the patient is asymptomatic, 781 00:38:45,784 --> 00:38:48,577 "breathes normally, and is tumor free. 782 00:38:48,661 --> 00:38:50,204 "These results are evidence 783 00:38:50,288 --> 00:38:53,332 "that a successful organ-regeneration strategy 784 00:38:53,416 --> 00:38:55,376 has been accomplished." 785 00:38:55,460 --> 00:38:59,005 [laughs] "And the procedure's success provides proof 786 00:38:59,089 --> 00:39:00,965 of the viability of this approach." 787 00:39:01,049 --> 00:39:02,425 [cheers and applause] 788 00:39:02,509 --> 00:39:05,469 To Dr. Macchiarini, who dared to make the cut. 789 00:39:05,553 --> 00:39:06,679 Cheers. 790 00:39:06,763 --> 00:39:08,180 - To Andemariam Beyene, 791 00:39:08,264 --> 00:39:11,142 who bravely risked his life for science. 792 00:39:11,226 --> 00:39:12,351 Cheers. 793 00:39:12,435 --> 00:39:13,936 And last but not least, 794 00:39:14,020 --> 00:39:16,022 to The motherfucking "Lancet" 795 00:39:16,106 --> 00:39:18,691 for publishing our research article. 796 00:39:18,775 --> 00:39:21,277 Cheers! - Skol, Anders. 797 00:39:21,361 --> 00:39:24,030 - Nathan, tack. 798 00:39:24,114 --> 00:39:25,948 - So published in "The Lancet"-- 799 00:39:26,032 --> 00:39:28,659 you're halfway to a Nobel. 800 00:39:28,743 --> 00:39:30,119 This is shit. 801 00:39:30,203 --> 00:39:32,204 You'd think they would have sprung for better bubbly. 802 00:39:32,288 --> 00:39:35,166 - Then feel free to steal someone else's. 803 00:39:35,250 --> 00:39:38,044 - Fantastic. - Cheers. 804 00:39:38,128 --> 00:39:39,921 - I'm surprised to see you here, 805 00:39:40,005 --> 00:39:41,839 knowing how you feel about Dr. Macchiarini. 806 00:39:41,923 --> 00:39:43,716 - Well, free champagne is free champagne-- 807 00:39:43,800 --> 00:39:45,051 or whatever this is. - Of course. 808 00:39:45,135 --> 00:39:47,929 - You must all be on cloud nine. 809 00:39:48,013 --> 00:39:49,221 - I'm excited, of course, 810 00:39:49,305 --> 00:39:50,932 though I also have the feeling of-- 811 00:39:51,016 --> 00:39:53,184 What do you call it? Impostor's syndrome. 812 00:39:53,268 --> 00:39:54,310 - Why? 813 00:39:54,394 --> 00:39:56,062 You're running Macchiarini's rat trials. 814 00:39:56,146 --> 00:39:58,981 - Which are still in progress. 815 00:39:59,065 --> 00:40:01,359 Macchiarini included my name in the byline, 816 00:40:01,443 --> 00:40:04,946 but I have yet to submit my results. 817 00:40:05,030 --> 00:40:07,406 - Welcome to the world of scientific publishing. 818 00:40:07,490 --> 00:40:09,575 As I recall someone once saying, 819 00:40:09,659 --> 00:40:11,911 "Competition fuels progress." 820 00:40:11,995 --> 00:40:13,913 - [chuckles] 821 00:40:13,997 --> 00:40:16,916 [indistinct chatter] 822 00:40:17,000 --> 00:40:19,585 [dramatic music] 823 00:40:19,669 --> 00:40:26,551 ♪ ♪ 824 00:40:44,611 --> 00:40:45,987 - Okay. - Here we go. 825 00:40:46,071 --> 00:40:47,989 Watch out for the chair. 826 00:40:48,073 --> 00:40:50,241 - [laughing] Yeah, but I can't watch anything. 827 00:40:50,325 --> 00:40:51,701 Okay. 828 00:40:51,785 --> 00:40:54,412 - Okay, you can open your eyes. - No. 829 00:40:54,496 --> 00:40:56,998 - You said you wanted to start playing again. 830 00:40:57,082 --> 00:40:58,916 - We can do a duet. - Wow. 831 00:40:59,000 --> 00:41:01,002 Yeah, we can do a duet. 832 00:41:01,086 --> 00:41:02,837 This is incredible. Thank you. 833 00:41:02,921 --> 00:41:04,672 Careful with your stitches. - Aw. 834 00:41:04,756 --> 00:41:06,424 - Love, come here. 835 00:41:06,508 --> 00:41:09,260 Thank you so much. [smooches] Wow, this is so cool. 836 00:41:09,344 --> 00:41:11,345 But first, I have to remember how to play. 837 00:41:11,429 --> 00:41:13,723 - Oh, let me get my phone. - This is so cool. 838 00:41:13,807 --> 00:41:16,350 Thank you. 839 00:41:16,434 --> 00:41:18,394 [playing Chopin's "Nocturne Op. 9, No. 2"] 840 00:41:18,478 --> 00:41:20,438 [laughs] 841 00:41:20,522 --> 00:41:22,523 ♪ ♪ 842 00:41:22,607 --> 00:41:24,859 [Benita chuckles] 843 00:41:24,943 --> 00:41:31,950 ♪ ♪ 844 00:41:33,243 --> 00:41:36,287 - * Knowing I'll be missing ♪ 845 00:41:36,371 --> 00:41:40,875 ♪ Christmas Eve in my hometown ♪ 846 00:41:40,959 --> 00:41:43,961 - Thank you. - Mm. 847 00:41:44,045 --> 00:41:45,713 - Are you okay? 848 00:41:45,797 --> 00:41:48,883 - Yeah. Christmas, family... 849 00:41:48,967 --> 00:41:51,510 holidays, you know? 850 00:41:51,594 --> 00:41:53,888 - It makes you sad? 851 00:41:53,972 --> 00:41:56,599 - Not really, not this year. 852 00:41:56,683 --> 00:41:58,518 We feel like a family. 853 00:42:00,979 --> 00:42:03,689 - You read my mind. 854 00:42:03,773 --> 00:42:05,024 Lizzi. 855 00:42:05,108 --> 00:42:07,360 - [breathes excitedly] 856 00:42:07,444 --> 00:42:08,736 - Wait. Hold on. 857 00:42:08,820 --> 00:42:11,989 What--what is going on? This feels like collusion. 858 00:42:12,073 --> 00:42:16,702 ♪ ♪ 859 00:42:16,786 --> 00:42:19,413 ♪ Through dreams and just pretending ♪ 860 00:42:19,497 --> 00:42:23,251 ♪ I'm there, and I'll be spending ♪ 861 00:42:23,335 --> 00:42:26,504 ♪ Christmas Eve in my hometown ♪ 862 00:42:26,588 --> 00:42:28,548 - What do you say, Mom? 863 00:42:30,550 --> 00:42:32,093 - What do you say? 864 00:42:32,177 --> 00:42:35,346 - * In my hometown ♪ 865 00:42:35,430 --> 00:42:38,474 [laughter] 866 00:42:38,558 --> 00:42:41,477 ♪ ♪ 867 00:42:41,561 --> 00:42:43,521 [device whirring] 868 00:42:47,192 --> 00:42:49,110 - Hey, come in. - Hello. 869 00:42:49,194 --> 00:42:51,570 - Hi. Please come in. 870 00:42:51,654 --> 00:42:53,739 Look... 871 00:42:53,823 --> 00:42:57,201 Mr. Beyene sent it. 872 00:42:57,285 --> 00:42:58,745 - Oh. 873 00:42:59,579 --> 00:43:02,957 [indistinct chatter on cell phone] 874 00:43:03,041 --> 00:43:06,127 - It's nice, isn't it? - Yeah. 875 00:43:06,211 --> 00:43:08,713 - I wish our work always ended like that. 876 00:43:08,797 --> 00:43:10,965 - Yes. 877 00:43:11,049 --> 00:43:13,134 Thank you for sharing that with me. 878 00:43:13,218 --> 00:43:15,970 - Sometimes it's nice to be reminded why we-- 879 00:43:16,054 --> 00:43:18,889 - Sacrifice. 880 00:43:18,973 --> 00:43:20,600 - So you, too? 881 00:43:20,684 --> 00:43:24,312 - Oh, you know, nothing big-- just girlfriends, children, 882 00:43:24,396 --> 00:43:26,105 probably a few years off my life. 883 00:43:26,189 --> 00:43:29,150 - Well, maybe we can build something together 884 00:43:29,234 --> 00:43:32,069 that will make it all worthwhile. 885 00:43:32,153 --> 00:43:33,947 - I think we can. 886 00:43:35,740 --> 00:43:37,783 - The funding for our transplant research 887 00:43:37,867 --> 00:43:39,327 is about to run out. 888 00:43:39,411 --> 00:43:41,829 - I'm sure "The Lancet" article garnered some attention. 889 00:43:41,913 --> 00:43:43,831 - Yes, we can capitalize on that momentum 890 00:43:43,915 --> 00:43:45,791 to secure a new grant, 891 00:43:45,875 --> 00:43:48,127 which will lead to more surgeries 892 00:43:48,211 --> 00:43:50,796 and to more money. 893 00:43:50,880 --> 00:43:53,132 - Around and around. 894 00:43:53,216 --> 00:43:55,635 - Until we can expand... 895 00:43:55,719 --> 00:43:58,012 globally. 896 00:43:58,096 --> 00:44:01,432 The goal is six operations within the next three months. 897 00:44:01,516 --> 00:44:03,809 [dramatic music] 898 00:44:03,893 --> 00:44:08,022 - You can produce that many custom tracheas in that time? 899 00:44:08,106 --> 00:44:11,192 - Yes, it can be done. 900 00:44:11,276 --> 00:44:13,945 But we need more patients. 901 00:44:14,029 --> 00:44:16,489 - Then let's find more patients. 902 00:44:16,573 --> 00:44:23,496 ♪ ♪